Phenotypes associated with this allele

• Allele Symbol: Mecp2^em1Dkatz
• Allele Name: endonuclease-mediated mutation 1, David Katz
• Allele ID: MGI:6158911
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Mecp2^em1Dkatz/Mecp2^+ Tyr^c-ch/Tyr^c-ch	FVB.Cg-Pde6b^+ Tyr^c-ch Mecp2^em1Dkatz/J	MGI:6159334
cx2	Mecp2^em1Dkatz/Mecp2^em1Dkatz Tyr^c-ch/Tyr^c-ch	FVB.Cg-Pde6b^+ Tyr^c-ch Mecp2^em1Dkatz/J	MGI:6159335
cx3	Mecp2^em1Dkatz/Y Tyr^c-ch/Tyr^c-ch	FVB.Cg-Pde6b^+ Tyr^c-ch Mecp2^em1Dkatz/J	MGI:6159336

Genotype
MGI:6159334

cx1

• Allelic Composition: Mecp2^em1Dkatz/Mecp2⁺; Tyr^c-ch/Tyr^c-ch
• Genetic Background: FVB.Cg-Pde6b⁺ Tyr^c-ch Mecp2^em1Dkatz/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal locomotor behavior ( J:101977 )

♀ • females exhibit a locomotor phenotype onset as early as 14 weeks of age

reproductive system

reproductive system phenotype ( J:101977 )

♀N • fertility is normal

Genotype
MGI:6159335

cx2

• Allelic Composition: Mecp2^em1Dkatz/Mecp2^em1Dkatz; Tyr^c-ch/Tyr^c-ch
• Genetic Background: FVB.Cg-Pde6b⁺ Tyr^c-ch Mecp2^em1Dkatz/J

reproductive system

female infertility ( J:101977 )

♀

Genotype
MGI:6159336

cx3

• Allelic Composition: Mecp2^em1Dkatz/Y; Tyr^c-ch/Tyr^c-ch
• Genetic Background: FVB.Cg-Pde6b⁺ Tyr^c-ch Mecp2^em1Dkatz/J

mortality/aging

premature death ( J:101977 )

♂ • males die by 10 weeks of age