Phenotypes associated with this allele

• Allele Symbol: Myzap^tm1Norf
• Allele Name: targeted mutation 1, Norbert Frey
• Allele ID: MGI:6158943
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Myzap^tm1Norf/Myzap^tm1Norf	involves: C57BL/6J	MGI:6159102

Genotype
MGI:6159102

hm1

• Allelic Composition: Myzap^tm1Norf/Myzap^tm1Norf
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:231032 )

N • no (ultra)structural abnormalities

N • no ventricular dilatation nor pulmonary congestion

N • no difference in QRS duration or QT or PQ interval

N • no difference in spontaneous or induced arrhythmias (neither ventricular nor atrial) nor in AV nodal conduction

abnormal cardiac muscle tissue morphology ( J:231032 )

• significantly increased cardiomyocyte surface area after transverse aortic constriction (TAC)

increased heart weight ( J:231032 )

• exaggerated increase in heart weight, heart weight to body weight ratio and ventricular weight to body weight ratio after transverse aortic constriction (TAC)

cardiac hypertrophy ( J:231032 )

• exaggerated increase in heart size after transverse aortic constriction (TAC)

cardiac fibrosis ( J:231032 )

• after transverse aortic constriction (TAC)

decreased cardiac muscle contractility ( J:231032 )

• after transverse aortic constriction (TAC)

muscle

abnormal cardiac muscle tissue morphology ( J:231032 )

• significantly increased cardiomyocyte surface area after transverse aortic constriction (TAC)

decreased cardiac muscle contractility ( J:231032 )

• after transverse aortic constriction (TAC)

mortality/aging

mortality/aging ( J:231032 )

N • viable and normal lifespan

increased susceptibility to induced morbidity/mortality ( J:231032 )

• significantly increased mortality rate after transverse aortic constriction (TAC)

nervous system

abnormal action potential ( J:231032 )

• significantly shorter ventricular action potential durations at paced cycle length of 100200 ms

respiratory system

increased lung weight ( J:231032 )

• pronounced increase in lung weight to body weight ratio after transverse aortic constriction (TAC)

reproductive system

reproductive system phenotype ( J:231032 )

N • fertile

growth/size/body

increased heart weight ( J:231032 )

• exaggerated increase in heart weight, heart weight to body weight ratio and ventricular weight to body weight ratio after transverse aortic constriction (TAC)

cardiac hypertrophy ( J:231032 )

• exaggerated increase in heart size after transverse aortic constriction (TAC)

increased lung weight ( J:231032 )

• pronounced increase in lung weight to body weight ratio after transverse aortic constriction (TAC)