All Phenotypes Slurp2<tm1.1Sgy> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Slurp2^tm1.1Sgy
targeted mutation 1.1, Stephen G Young
MGI:6159751

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Slurp2^tm1.1Sgy/Slurp2^tm1.1Sgy	involves: 129P2/OlaHsd * C57BL/6	MGI:6159891
cx2	Slurp1^tm1.1Sgy/Slurp1⁺ Slurp2^tm1.1Sgy/Slurp2⁺	involves: 129P2/OlaHsd * C57BL/6	MGI:6159892

Allelic Composition	Slurp2^tm1.1Sgy/Slurp2^tm1.1Sgy
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slurp2^tm1.1Sgy mutation (0 available); any Slurp2 mutation (13 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

integument

impaired skin barrier function ( J:231067 )

• increased trans-epidermal water loss from paw skin

• trans-epidermal water loss from ear or back skin

abnormal epidermis stratum corneum morphology ( J:231067 )

• contains many tiny lipid droplets in volar surface of paws

hyperkeratosis ( J:231067 )

• on volar surface of paws

homeostasis/metabolism

impaired skin barrier function ( J:231067 )

• increased trans-epidermal water loss from paw skin

• trans-epidermal water loss from ear or back skin

adipose tissue

decreased total fat pad weight ( J:231067 )

decreased percent body fat/body weight ( J:231067 )

growth/size/body

slow postnatal weight gain ( J:231067 )

behavior/neurological

limb grasping ( J:231067 )

• clasping of hindlimbs in tail suspension test

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
palmoplantar keratosis		DOID:3390		J:231067

Allelic Composition	Slurp1^tm1.1Sgy/Slurp1⁺ Slurp2^tm1.1Sgy/Slurp2⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slurp1^tm1.1Sgy mutation (0 available); any Slurp1 mutation (16 available)
Slurp2^tm1.1Sgy mutation (0 available); any Slurp2 mutation (13 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

integument

integument phenotype ( J:231067 )

N	• no hyperkeratosis of paw skin

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24