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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Pnldc1em2Nkn
endonuclease-mediated mutation 2, Toru Nakano
MGI:6159928
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Pnldc1em2Nkn/Pnldc1em2Nkn involves: C57BL/6 MGI:6159937


Genotype
MGI:6159937
hm1
Allelic
Composition		 Pnldc1em2Nkn/Pnldc1em2Nkn
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pnldc1em2Nkn mutation (1 available); any Pnldc1 mutation (28 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
small testis ( J:262084 )
• approximately half of normal size
arrest of spermatogenesis ( J:262084 )
• at both meiotic and post-meiotic phases
• no sperm in epididymis
male infertility ( J:262084 )
• no sperm in epididymis

endocrine/exocrine glands
small testis ( J:262084 )
• approximately half of normal size

cellular
abnormal DNA methylation ( J:262084 )
• significantly impaired DNA methylation of types A and Gf LINE-1 genes in germ cells of 10-day old mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory