All Phenotypes Pnldc1<em2Nkn> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Pnldc1^em2Nkn
endonuclease-mediated mutation 2, Toru Nakano
MGI:6159928

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pnldc1^em2Nkn/Pnldc1^em2Nkn	involves: C57BL/6	MGI:6159937

Allelic Composition	Pnldc1^em2Nkn/Pnldc1^em2Nkn
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pnldc1^em2Nkn mutation (1 available); any Pnldc1 mutation (28 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

small testis ( J:262084 )

• approximately half of normal size

arrest of spermatogenesis ( J:262084 )

• at both meiotic and post-meiotic phases

• no sperm in epididymis

male infertility ( J:262084 )

• no sperm in epididymis

endocrine/exocrine glands

small testis ( J:262084 )

• approximately half of normal size

cellular

abnormal DNA methylation ( J:262084 )

• significantly impaired DNA methylation of types A and Gf LINE-1 genes in germ cells of 10-day old mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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