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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cdk1tm3Kald
targeted mutation 3, Philipp Kaldis
MGI:6160101
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Cdk1tm3Kald/Cdk1+
Tg(Stra8-icre)1Reb/0 		involves: 129 * C57BL/6 * FVB/NJ MGI:6201526
cn2
 		Cdk1tm3Kald/Cdk1+
Fbxo43tm1.2Kald/Fbxo43tm1.2Kald
Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+ 		involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL MGI:6201527


Genotype
MGI:6201526
cn1
Allelic
Composition		 Cdk1tm3Kald/Cdk1+
Tg(Stra8-icre)1Reb/0
Genetic
Background		 involves: 129 * C57BL/6 * FVB/NJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdk1tm3Kald mutation (0 available); any Cdk1 mutation (21 available)
Tg(Stra8-icre)1Reb mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
azoospermia ( J:251984 )
• tubules contain only Sertoli cells with only rare spermatogonia

endocrine/exocrine glands

cellular
azoospermia ( J:251984 )
• tubules contain only Sertoli cells with only rare spermatogonia




Genotype
MGI:6201527
cn2
Allelic
Composition		 Cdk1tm3Kald/Cdk1+
Fbxo43tm1.2Kald/Fbxo43tm1.2Kald
Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdk1tm3Kald mutation (0 available); any Cdk1 mutation (21 available)
Fbxo43tm1.2Kald mutation (0 available); any Fbxo43 mutation (29 available)
Gt(ROSA)26Sortm1(cre/ERT)Brn mutation (1 available); any Gt(ROSA)26Sor mutation (993 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:251984 )
• within 4 to 5 days after treatment with tamoxifen at around age P21

reproductive system
azoospermia ( J:251984 )
• after treatment with tamoxifen at around age P21
arrest of male meiosis ( J:251984 )
• early in diplotene with some progression into metaphase
increased male germ cell apoptosis ( J:251984 )
• after treatment with tamoxifen at around age P21

cellular
azoospermia ( J:251984 )
• after treatment with tamoxifen at around age P21
arrest of male meiosis ( J:251984 )
• early in diplotene with some progression into metaphase
increased male germ cell apoptosis ( J:251984 )
• after treatment with tamoxifen at around age P21




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory