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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ftxtm1.1Oka
targeted mutation 1.1, Masaru Okabe
MGI:6160397
Summary 5 genotypes


Genotype
MGI:6287773
hm1
Allelic
Composition		 Ftxtm1.1Oka/Ftxtm1.1Oka
Genetic
Background		 C57BL/6N-Ftxtm1.1Oka
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ftxtm1.1Oka mutation (0 available); any Ftx mutation (5 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
abnormal anterior eye segment morphology ( J:268562 )
• large defects in ocular tissues, typically the absence of tissues in some mice
• however, layers of neural retina are normal
abnormal iris morphology ( J:268562 )
• gaps in some mice
aphakia ( J:268562 )
• in most severely affected mice
• however, retinal epithelial tissue forms
microphthalmia ( J:268562 )
• small to almost absent in some mice

cellular




Genotype
MGI:6287830
ht2
Allelic
Composition		 Ftxtm1.1Oka/Ftx+
Genetic
Background		 C57BL/6N-Ftxtm1.1Oka
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ftxtm1.1Oka mutation (0 available); any Ftx mutation (5 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
microphthalmia ( J:268562 )
• small to almost absent in some mice




Genotype
MGI:6160401
ht3
Allelic
Composition		 Ftxtm1.1Oka/Ftx+
Genetic
Background		 (C57BL/6N x B6(Cg)-Ftxtm1.1Oka)F1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ftxtm1.1Oka mutation (0 available); any Ftx mutation (5 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:260691 )
• mice are viable and fertile with normal XCI imprinting




Genotype
MGI:6160399
ot4
Allelic
Composition		 Ftxtm1.1Oka/Y
Genetic
Background		 B6(Cg)-Ftxtm1.1Oka
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ftxtm1.1Oka mutation (0 available); any Ftx mutation (5 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:260691 )
• mice are viable and fertile with normal XCI imprinting




Genotype
MGI:6287831
ot5
Allelic
Composition		 Ftxtm1.1Oka/Y
Genetic
Background		 C57BL/6N-Ftxtm1.1Oka
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ftxtm1.1Oka mutation (0 available); any Ftx mutation (5 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
vision/eye phenotype ( J:268562 )
N
• mice exhibit normal eye size




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory