Phenotypes associated with this allele

• Allele Symbol: Tg(tetO-Sri)1Hhv
• Allele Name: transgene insertion 1, Hector H Valdivia
• Allele ID: MGI:6160738
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Tg(Ins2-rtTA)2Efr/0 Tg(tetO-Sri)1Hhv/0	involves: C57BL/6 * CBA	MGI:6160821

Genotype
MGI:6160821

cx1

• Allelic Composition: Tg(Ins2-rtTA)2Efr/0; Tg(tetO-Sri)1Hhv/0
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased circulating insulin level ( J:246708 )

♂ • in glucose-stimulation in doxycycline-treated male mice and ex vivo islets

improved glucose tolerance ( J:246708 )

♂ • in doxycycline-treated male mice fed a high-fat diet

♂ • however, insulin sensitivity is normal

endocrine/exocrine glands

abnormal pancreas physiology ( J:246708 )

♂ • islet cells from doxycycline-treated male mice fed a high-fat diet exhibit improved cytosolic calcium fluxes and increased endoplasmic calcium stores

growth/size/body

growth/size/body region phenotype ( J:246708 )

♂N • doxycycline-treated male mice exhibit normal weight change in response to being fed a high-fat diet