Phenotypes associated with this allele

• Allele Symbol: Cntd1^{tm1e.1(KOMP)Wtsi}
• Allele Name: targeted mutation 1e.1, Wellcome Trust Sanger Institute
• Allele ID: MGI:6161819
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cntd1^tm1e.1(KOMP)Wtsi/Cntd1^tm1e.1(KOMP)Wtsi	involves: C57BL/6N	MGI:6161824

Genotype
MGI:6161824

hm1

• Allelic Composition: Cntd1^{tm1e.1(KOMP)Wtsi}/Cntd1^{tm1e.1(KOMP)Wtsi}
• Genetic Background: involves: C57BL/6N
• Cell Lines: EPD0190_3_E03

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

azoospermia ( J:215796 )

♂ • no epididymal spermatozoa are found in homozygous mutant males

♂ • loss of spermatozoa in the seminiferous tubules

♂ • GCNA-1associated spermatogonia and early spermatocytes were unaffected

abnormal spermatid morphology ( J:215796 )

♂ • no postmeiotic spermatids in testes from mutant males

abnormal spermatocyte morphology ( J:215796 )

♂ • testes from mutant males exhibit increased apoptosis of spermatocytes

abnormal female meiosis ( J:215796 )

♀ • homozygous mutant females exhibit meiotic phenotypes

abnormal male meiosis ( J:215796 )

♂ • early recombination and synapsis events are normal in males

♂ • mutants are severely defective in meiotic crossover formation

♂ • the number of chiasmata resulting from crossovers was also substantially reduced in diakinesis-stage spermatocytes in mutant males

endocrine/exocrine glands

small testis ( J:215796 )

♂ • homozygous mutant males show significantly decreased testis size compared with controls

reproductive system

azoospermia ( J:215796 )

♂ • no epididymal spermatozoa are found in homozygous mutant males

♂ • loss of spermatozoa in the seminiferous tubules

♂ • GCNA-1associated spermatogonia and early spermatocytes were unaffected

abnormal spermatid morphology ( J:215796 )

♂ • no postmeiotic spermatids in testes from mutant males

abnormal spermatocyte morphology ( J:215796 )

♂ • testes from mutant males exhibit increased apoptosis of spermatocytes

abnormal female meiosis ( J:215796 )

♀ • homozygous mutant females exhibit meiotic phenotypes

abnormal male meiosis ( J:215796 )

♂ • early recombination and synapsis events are normal in males

♂ • mutants are severely defective in meiotic crossover formation

♂ • the number of chiasmata resulting from crossovers was also substantially reduced in diakinesis-stage spermatocytes in mutant males

small testis ( J:215796 )

♂ • homozygous mutant males show significantly decreased testis size compared with controls

female infertility ( J:215796 )

♀ • homozygous mutant females are sterile

male infertility ( J:215796 )

♂ • homozygous mutant males are sterile