mortality/aging
• of three of four mice kindled mice
• one of three mice exhibiting spontaneous seizures exhibits premature death
|
behavior/neurological
N |
• mice exhibit normal cued conditioning, grip strength and tail flick task response
|
• mice take longer to find a hidden platform or crawl onto a marked platform compared with wild-type mice
• mice exhibit normal grip strength
|
• mice exhibit equal preference for two identical objects in a novel object task
|
• in an open field test, mice exhibit increased activity including in the center area compared with wild-type mice
|
• mice take longer to cross a beam, exhibit more hindlimb slips, and often use their forelimbs to drag themselves across unlike wild-type mice
• however, mice exhibit normal performance on an accelerated rotarod
|
• in an open field test, mice exhibit increased activity including in the center area compared with wild-type mice
|
hemiplegia
(
J:262419
)
• reversible hemiplegia or hemipareses in 14 of 35 mice at between 8 and 28 weeks of age often during handling
• hemiplegias become bilateral and alternated within the same spell
|
hemiparesis
(
J:262419
)
• reversible hemiplegia or hemipareses in 14 of 35 mice at between 8 and 28 weeks of age often during handling
|
• longer latency to response
|
• reduced latency to seizure onset induced by flurothyl
|
• longer after discharge duration after achieving the fully kindled state
|
nervous system
• reduced latency to seizure onset induced by flurothyl
|
• longer after discharge duration after achieving the fully kindled state
|
• increased excitability with polyspikes in 5 of 6 mice induced by 30 1 Hz pulses with gradual increase in number of spikes and area, increased area of polyspike in response to paired-pulse stimulation, and larger spreading depression duration and area
• however, the fEPSP slope and amplitude are normal during repetitive stimulation
|
growth/size/body
N |
• mice exhibit normal trunk length
|
• at 6, 8, 9 and 11 weeks in male mice
• however, female mice exhibit normal weight
|
muscle
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
alternating hemiplegia of childhood | DOID:0050635 |
OMIM:104290 OMIM:614820 OMIM:PS104290 |
J:262419 |