Phenotypes associated with this allele

• Allele Symbol: Pm20d1^em1Brsp
• Allele Name: endonuclease-mediated mutation 1, Bruce M. Spiegelman
• Allele ID: MGI:6162684
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pm20d1^em1Brsp/Pm20d1^em1Brsp	C57BL/6J-Pm20d1^em1Brsp	MGI:6201144

Genotype
MGI:6201144

hm1

• Allelic Composition: Pm20d1^em1Brsp/Pm20d1^em1Brsp
• Genetic Background: C57BL/6J-Pm20d1^em1Brsp

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal nociception after inflammation ( J:264104 )

• mice exhibit reduced paw-licking and constriction behaviors in response to formalin and acetic acid, respectively

• response to thermal pain is similar to wild-type

decreased chemically-elicited antinociception ( J:264104 )

• mice exhibit reduced paw-licking and constriction behaviors in response to formalin and acetic acid, respectively

• response to thermal pain is similar to wild-type

homeostasis/metabolism

abnormal adaptive thermogenesis ( J:264104 )

• mice maintain a higher body temperature during cold exposure than controls

impaired glucose tolerance ( J:264104 )

• after 16 weeks on high fat diet

insulin resistance ( J:264104 )

• reduced insulin sensitivity after 19 weeks on Western diet

abnormal lipid metabolism ( J:264104 )

• N-acyl amino acid (NAA) hydrolysis activity is reduced or abolished in plasma and multiple tissues

• NAA synthase activity is abolished in the liver