Allele Symbol Allele Name Allele ID |
Atp1a3tm1.1Tmklh targeted mutation 1.1, Karin Lykke-Hartmann MGI:6163502 |
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Summary |
2 genotypes
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• induced by pentylenetetrazole
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• fewer than expected mice are present at 3 weeks of age
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N |
• mice do not exhibit spontaneous seizures
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• in an elevated plus maze, mice do not discriminate between open and closed arms and spend more time in the open arms compared with wild-type mice
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• induced by pentylenetetrazole with increased lethality
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• mice exhibit reduced latency to re-enter the dark compartment compared with wild-type mice
• however, clonazepam-treatment normalizes performance
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• minimal habituation in an open field
• in response to handling
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• in the Barnes Maze, mice do not exhibit increased latency to enter the escape tube but walk past the tube multiple times before entering compared with wild-type mice
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• in an open field test
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N |
• CA1 pyramidal neurons exhibit normal excitability
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• induced by pentylenetetrazole with increased lethality
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• large number of pyknotic nuclei within the dentate gyrus granule cell layer
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• reduced hippocampal dentate gyrus granule cells
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• reduced rate of decay and slower initial discharge rate
• however, mice exhibit normal threshold of induction and steady-state electroresponsive behavior
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• induced by pentylenetetrazole
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
alternating hemiplegia of childhood | DOID:0050635 |
OMIM:104290 OMIM:614820 OMIM:PS104290 |
J:254463 |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/02/2024 MGI 6.24 |
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