All Phenotypes Spata20<Tn(pb-Act-RFP)1.1Zhu> MGI Mouse

teratozoospermia ( J:262160 )

• most sperm show abnormal morphology like tail bending, decollation and head deformities

abnormal sperm flagellum morphology ( J:262160 )

• sperm show tail bending

abnormal sperm head morphology ( J:262160 )

• most sperm show head deformities

• however, the acrosome is present and sperm chromatin integrity is normal

abnormal spermatid morphology ( J:262160 )

• at 10 to 12-weeks of age, mature spermatids in cauda epididymides are markedly decreased, and cauda epididymides are full of round spermatids with abnormally shaped nuclei shedding from the seminiferous tubules

abnormal manchette morphology ( J:262160 )

• elongating spermatids show abnormal manchette morphology

• after step 10 of spermiogenesis, the microtubules of manchette are unable to move caudally down the nucleus and the perinuclear ring of the manchette fails to constrict; as a result, the portion of the nucleus next to the connecting piece is wider than in wild-type controls, causing a hammer-head sperm shape

abnormal manchette perinuclear ring morphology ( J:262160 )

• perinuclear ring fails to constrict as the manchette moves toward the spermatid tail

decreased male germ cell number ( J:262160 )

• at 10 to 12-weeks of age, the proportion of elongated spermatids is lower than that in wild-type testes, with only a few mature spermatids found in the cauda epididymides

oligozoospermia ( J:262160 )

• at 10 to 12-weeks of age, the total count of cauda epididymides sperm is dramatically decreased

decreased sperm progressive motility ( J:262160 )

asthenozoospermia ( J:262160 )

• at 10 to 12-weeks of age, the percentages of motile and progressive sperm are dramatically decreased

small testis ( J:262160 )

decreased testis weight ( J:262160 )

abnormal spermiogenesis ( J:262160 )

• at 10 to 12-weeks of age, post-meiotic development of elongating spermatids in stage VII seminiferous tubules is disrupted

male infertility ( J:262160 )

• male homozygotes are sterile due to severe oligoasthenoteratozoospermia

• mating behavior is normal