Phenotypes associated with this allele

• Allele Symbol: Npffr2^tm1.2Ics
• Allele Name: targeted mutation 1.2, Mouse Clinical Institute
• Allele ID: MGI:6163806
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Npffr2^tm1.2Ics/Npffr2^tm1.2Ics	involves: C57BL/6N	MGI:6164154

Genotype
MGI:6164154

hm1

• Allelic Composition: Npffr2^tm1.2Ics/Npffr2^tm1.2Ics
• Genetic Background: involves: C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

decreased macrophage proliferation ( J:245025 )

• mice exhibit reduced adipose tissue macrophage proliferation in epididymal and inguinal white adipose tissue

• adipose tissue macrophages fail to upregulate proliferation in response to appetite-reducing neuropeptide FF (NPFF)

decreased macrophage cell number ( J:245025 )

• mice exhibit reduced adipose tissue macrophages numbers in epididymal and inguinal white adipose tissue, without an effect on peripheral blood hematology

abnormal macrophage activation involved in immune response ( J:245025 )

• M2 activation is abolished in adipose tissue macrophages

immune system

decreased macrophage proliferation ( J:245025 )

• mice exhibit reduced adipose tissue macrophage proliferation in epididymal and inguinal white adipose tissue

• adipose tissue macrophages fail to upregulate proliferation in response to appetite-reducing neuropeptide FF (NPFF)

decreased macrophage cell number ( J:245025 )

• mice exhibit reduced adipose tissue macrophages numbers in epididymal and inguinal white adipose tissue, without an effect on peripheral blood hematology

abnormal macrophage activation involved in immune response ( J:245025 )

• M2 activation is abolished in adipose tissue macrophages

cellular

decreased macrophage proliferation ( J:245025 )

• mice exhibit reduced adipose tissue macrophage proliferation in epididymal and inguinal white adipose tissue

• adipose tissue macrophages fail to upregulate proliferation in response to appetite-reducing neuropeptide FF (NPFF)

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:245025 )

N • mice exhibit normal body weight, normal levels of basal glucose level, insulin, triglycerides, cholesterol, and non-esterified fatty acids, normal adipose tissue weight, and normal glucose tolerance test and insulin sensitivity test