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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Mkrn2tm1.1Bhj
targeted mutation 1.1, Bing-Hua Jiang
MGI:6163817
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Mkrn2tm1.1Bhj/Mkrn2tm1.1Bhj involves: 129P2/OlaHsd * C57BL/6J MGI:6163819


Genotype
MGI:6163819
hm1
Allelic
Composition
Mkrn2tm1.1Bhj/Mkrn2tm1.1Bhj
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mkrn2tm1.1Bhj mutation (0 available); any Mkrn2 mutation (24 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• both male and female homozygous mice exhibit decreased weight compared to controls

reproductive system
• the outer dense fiber is either absent or improperly arranged
• complete loss of the axoneme doublets in one side of the fibrous sheath
• disordered assembly of the '9 + 2' arrangement
• abnormal or missing acrosomes
• acrosomes are missing in some cases
• the number of round spermatids was significantly decreased
• the number of round spermatids was significantly decreased
• the ectoplasmic specialization arrangement is disrupted
• seminiferous tubules retained elongated spermatids among germ cells and did not release
• male mice are completely sterile

cellular
• the outer dense fiber is either absent or improperly arranged
• complete loss of the axoneme doublets in one side of the fibrous sheath
• disordered assembly of the '9 + 2' arrangement
• abnormal or missing acrosomes
• acrosomes are missing in some cases
• the number of round spermatids was significantly decreased
• the number of round spermatids was significantly decreased

endocrine/exocrine glands
• the ectoplasmic specialization arrangement is disrupted





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory