Phenotypes associated with this allele

• Allele Symbol: Qrfp^tm1Stak
• Allele Name: targeted mutation 1, Takeshi Sakurai
• Allele ID: MGI:6163999
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Qrfp^tm1Stak/Qrfp^tm1Stak	B6J.129-Qrfp^tm1Stak	MGI:6191703

Genotype
MGI:6191703

hm1

• Allelic Composition: Qrfp^tm1Stak/Qrfp^tm1Stak
• Genetic Background: B6J.129-Qrfp^tm1Stak

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased body fat mass ( J:250913 )

• at 30 weeks of age, mice fed a normal chow diet exhibit lower visceral and total fat mass than wild-type controls

• however, lean mass is similar to that of wild-type controls suggesting normal growth

decreased body weight ( J:250913 )

• under ad lib feeding of normal chow, body weight is lower by 8.3% for male and 9.6% for female mice relative to similarly-fed wild-type controls at 18 weeks of age

• under high-fat chow feeding, body weight is lower by 10.6% for male and 11.9% for female mice relative to similarly-fed wild-type controls at 18 weeks of age

homeostasis/metabolism

decreased circulating leptin level ( J:250913 )

• at 30 weeks of age, serum leptin level is significantly lower than that in wild-type controls

behavior/neurological

decreased food intake ( J:250913 )

• under ad lib feeding of normal chow, males eat on average 6% less than wild-type controls from 9 to 33 weeks of age

• however, metabolic rate (as measured by VO₂) and daily spontaneous locomotor activity are relatively normal, suggesting that mice are lean due to hypophagia

decreased coping response ( J:250913 )

• mice show a mild abnormality in the tail suspension test, suggesting the possibility that they are depressive or hypoactive

increased anxiety-related response ( J:250913 )

• in the elevated-plus maze test, mice make fewer entries and spend a shorter % of time in the open arms relative to wild-type controls, suggesting increased basal anxiety levels

decreased vertical activity ( J:250913 )

• in the open field test, mice exhibit decreased vertical activities relative to wild-type controls

decreased locomotor activity ( J:250913 )

• in the open field test, mice exhibit lower locomotor activity than wild-type controls when placed into the open field arena, suggesting hypoactivity in novel circumstances

• however, stereotypic behavior and time spent in the central area are normal

abnormal circadian sleep/wake cycle ( J:250913 )

• mice show decreased awake time esp. at the point of 3 h after the start of the dark period relative to wild-type controls

• however, overall amounts of wakefulness, non-rapid eye movement (NREM) sleep, and REM sleep in 12-hour light and dark periods are not significantly altered

abnormal non-rapid eye movement sleep pattern ( J:250913 )

• mice show increased non-REM sleep time esp. at the point of 2 and 3 h after the start of the dark period relative to wild-type controls

adipose tissue

decreased body fat mass ( J:250913 )

• at 30 weeks of age, mice fed a normal chow diet exhibit lower visceral and total fat mass than wild-type controls

• however, lean mass is similar to that of wild-type controls suggesting normal growth