Phenotypes associated with this allele

• Allele Symbol: Creg1^tm1Yal
• Allele Name: targeted mutation 1, Yaling Han
• Allele ID: MGI:6164127
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Creg1^tm1Yal/Creg1^+	involves: 129 * C57BL/6	MGI:6283819

Genotype
MGI:6283819

ht1

• Allelic Composition: Creg1^tm1Yal/Creg1⁺
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal physiological neovascularization ( J:262697 )

♂ • following ligation of the left femoral artery, male heterozygotes show a significant reduction in the ratio of left-to-right leg blood-flow recovery and markedly reduced capillary density (neovascularization) in ischemic hindlimb tissue relative to wild-type controls

♂ • notably, injection of adenoviral CREG1 into the gastrocnemius muscle partially increases neovascularization and tissue perfusion in the ischemic hindlimb

decreased heart left ventricle muscle contractility ( J:253911 )

• 28 days after myocardial ischemia/reperfusion (MI/R) injury, male heterozygotes exhibit significantly lower left ventricular (LV) fractional shortening and ejection fraction relative to wild-type controls

increased response of heart to induced stress ( J:253911 )

♂ • 28 days after MI/R injury, male heterozygotes exhibit significantly lower LV fractional shortening and ejection fraction and increased LV volume in diastole (LVVD), indicating decreased cardiac function relative to wild-type controls

increased myocardial infarct size ( J:253911 )

♂ • following MI/R injury, male heterozygotes exhibit a larger infarction size and area at risk at 2 hrs after reperfusion relative to wild-type controls

homeostasis/metabolism

increased response of heart to induced stress ( J:253911 )

♂ • 28 days after MI/R injury, male heterozygotes exhibit significantly lower LV fractional shortening and ejection fraction and increased LV volume in diastole (LVVD), indicating decreased cardiac function relative to wild-type controls

increased myocardial infarct size ( J:253911 )

♂ • following MI/R injury, male heterozygotes exhibit a larger infarction size and area at risk at 2 hrs after reperfusion relative to wild-type controls

abnormal autophagy ( J:253911 )

♂ • following MI/R injury, male heterozygotes show accumulation of LC3A and p62 in the ischemic border of the myocardium, indicating impaired myocardial autophagy

muscle

decreased heart left ventricle muscle contractility ( J:253911 )

• 28 days after myocardial ischemia/reperfusion (MI/R) injury, male heterozygotes exhibit significantly lower left ventricular (LV) fractional shortening and ejection fraction relative to wild-type controls

increased cardiomyocyte apoptosis ( J:253911 )

♂ • following MI/R injury, male heterozygotes show a significantly greater number of TUNEL+ cells in the ischemic border of the myocardium at 2 hrs after reperfusion relative to wild-type controls; expression of cleaved caspase-3 protein is enhanced at 15 min, 30 min and 2 hrs after reperfusion

cellular

abnormal autophagy ( J:253911 )

♂ • following MI/R injury, male heterozygotes show accumulation of LC3A and p62 in the ischemic border of the myocardium, indicating impaired myocardial autophagy

increased cardiomyocyte apoptosis ( J:253911 )

♂ • following MI/R injury, male heterozygotes show a significantly greater number of TUNEL+ cells in the ischemic border of the myocardium at 2 hrs after reperfusion relative to wild-type controls; expression of cleaved caspase-3 protein is enhanced at 15 min, 30 min and 2 hrs after reperfusion