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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Rnf128tm1.2Cmse
targeted mutation 1.2, Christine M Seroogy
MGI:6164139
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Rnf128tm1.2Cmse/Rnf128tm1.2Cmse involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:6164153


Genotype
MGI:6164153
hm1
Allelic
Composition
Rnf128tm1.2Cmse/Rnf128tm1.2Cmse
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rnf128tm1.2Cmse mutation (0 available); any Rnf128 mutation (10 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• adipose tissue macrophages show increased p-STAT6 levels and expression of arginase 1 and CD206, both of which are hallmarks of M2 activation

immune system
• adipose tissue macrophages show increased p-STAT6 levels and expression of arginase 1 and CD206, both of which are hallmarks of M2 activation

homeostasis/metabolism
N
• mice exhibit normal body weight, basal glucose level, insulin level, glucose tolerance test, insulin sensitivity test, and adipose tissue weight





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory