Phenotypes associated with this allele

• Allele Symbol: Rnf128^tm1.2Cmse
• Allele Name: targeted mutation 1.2, Christine M Seroogy
• Allele ID: MGI:6164139
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rnf128^tm1.2Cmse/Rnf128^tm1.2Cmse	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:6164153

Genotype
MGI:6164153

hm1

• Allelic Composition: Rnf128^tm1.2Cmse/Rnf128^tm1.2Cmse
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal macrophage physiology ( J:245025 )

• adipose tissue macrophages show increased p-STAT6 levels and expression of arginase 1 and CD206, both of which are hallmarks of M2 activation

immune system

abnormal macrophage physiology ( J:245025 )

• adipose tissue macrophages show increased p-STAT6 levels and expression of arginase 1 and CD206, both of which are hallmarks of M2 activation

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:245025 )

N • mice exhibit normal body weight, basal glucose level, insulin level, glucose tolerance test, insulin sensitivity test, and adipose tissue weight