Phenotypes associated with this allele

• Allele Symbol: Dlgap1^tm1Grnt
• Allele Name: targeted mutation 1, Seth G N Grant
• Allele ID: MGI:6164155
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dlgap1^tm1Grnt/Dlgap1^tm1Grnt	involves: 129 * C57BL/6J	MGI:6196013
ht2	Dlgap1^tm1Grnt/Dlgap1^+	involves: 129 * C57BL/6J	MGI:6196014

Genotype
MGI:6196013

hm1

• Allelic Composition: Dlgap1^tm1Grnt/Dlgap1^tm1Grnt
• Genetic Background: involves: 129 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:262577 )

N • mice exhibit normal behavior in an open field test and a forced swim test nest building with normal nest building, paired pulse inhibition and sucrose preference

N • male mice exhibit reduced grooming bouts compared with heterozygous mice but are indistinguishable from wild-type mice

abnormal emotion/affect behavior ( J:262577 )

♂ • male, but not female, mice exhibit fewer digging bouts compared with wild-type mice

abnormal social investigation ( J:262577 )

• male mice exhibit fewer entries into the zone containing a mouse with reduced distance traveled in the zone compared with wild-type mice

• mice spend as much time investigating an object as another mouse (rearing) unlike wild-type mice and shorter latency to sniff the object compared with wild-type mice

Genotype
MGI:6196014

ht2

• Allelic Composition: Dlgap1^tm1Grnt/Dlgap1⁺
• Genetic Background: involves: 129 * C57BL/6J

behavior/neurological

increased grooming behavior ( J:262577 )

♂ • male mice exhibit more bouts of grooming and longer time grooming in a splash test compared with wild-type mice

abnormal social investigation ( J:262577 )

• male mice exhibit fewer entries into the zone containing a mouse with reduced distance traveled in the zone compared with wild-type mice

• mice spend as much time investigating an object as another mouse (rearing) unlike wild-type mice