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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Trim8tm1Hbsh
targeted mutation 1, H-B Shu
MGI:6164179
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Trim8tm1Hbsh/Trim8tm1Hbsh involves: 129S6/SvEvTac MGI:6825760


Genotype
MGI:6825760
hm1
Allelic
Composition
Trim8tm1Hbsh/Trim8tm1Hbsh
Genetic
Background
involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trim8tm1Hbsh mutation (0 available); any Trim8 mutation (28 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• after oral administration of Salmonella typhimurium, mice exhibit earlier death onset and a higher percentage of lethality within 12 days post-infection than wild-type controls
• after i.p. injection of poly(I:C) plus D-galactosamine or LPS, mice exhibit earlier death onset and a higher percentage of lethality within 42 h post-injection relative to wild-type controls

immune system
N
• untreated mice exhibit normal immune cell development with no significant alterations in total cell numbers and compositions of major immune cells in spleens, thymi, and lymph nodes
• poly(I:C)- and LPS- but not Sendai virus (SeV)-, PGN- or R848-induced secretion of IFN-beta, TNF, and IL6 is significantly increased in bone marrow-derived macrophages (BMDMs)
• 2 h after i.p. injection of poly(I:C) plus D-galactosamine or LPS, mice exhibit significantly higher serum CCL5 (also known as RANTES) levels than wild-type controls
• 2 h after i.p. injection of poly(I:C) plus D-galactosamine or LPS, mice exhibit significantly higher serum IL6 levels than wild-type controls
• 2 h after i.p. injection of poly(I:C) plus D-galactosamine or LPS, mice exhibit significantly higher serum TNF levels than wild-type controls
• poly(I:C)- and LPS-induced transcription of Ccl5 [chemokine (C-C motif) ligand 5, also known as Rantes] is significantly increased in bone marrow-derived macrophages (BMDMs) and bone marrow-derived dendritic cells (BMDCs)
• poly(I:C)- and LPS- but not Sendai virus (SeV)-induced transcription of Ccl5 is markedly increased in mouse embryonic fibroblasts (MEFs)
• reconstitution of TRIM8 markedly inhibits poly(I:C)- and LPS-triggered transcription of Ccl5 in MEFs
• induction of Ccl5 mRNA by R848, PGN, or Sendai virus is normal in BMDMs and BMDCs
• poly(I:C)- and LPS-induced transcription of Ifnb1 is significantly increased in BMDMs and BMDCs
• poly(I:C)- and LPS- but not Sendai virus (SeV)-, PGN- or R848-induced secretion of IFN-beta is significantly increased in BMDMs
• poly(I:C)- and LPS- but not SeV-induced transcription of Ifnb1 is markedly increased in MEFs
• reconstitution of TRIM8 markedly inhibits poly(I:C)- and LPS-triggered transcription of Ifnb1 in MEFs
• induction of Ifnb1 mRNA by R848, PGN, or Sendai virus is normal in BMDMs and BMDCs
• TNF- and IL-1beta-triggered transcription of Il6 is significantly impaired in MEFs and BMDCs
• reconstitution of TRIM8 markedly potentiates TNF- and IL-1beta-triggered transcription of Il6 in MEFs
• poly(I:C)- and LPS-induced transcription of Il6 is significantly increased in BMDMs and BMDCs
• poly(I:C)- and LPS- but not Sendai virus (SeV)-, PGN- or R848-induced secretion of IL6 is significantly increased in BMDMs
• poly(I:C)- and LPS- but not SeV-induced transcription of Il6 is markedly increased in MEFs
• reconstitution of TRIM8 markedly inhibits poly(I:C)- and LPS-triggered transcription of Il6 in MEFs
• induction of Il6 mRNA by R848, PGN, or Sendai virus is normal in BMDMs and BMDCs
• TNF- and IL-1beta-triggered transcription of Tnf is significantly impaired in MEFs and BMDCs
• reconstitution of TRIM8 markedly potentiates TNF- and IL-1beta-triggered transcription of Tnf in MEFs
• poly(I:C)- and LPS-induced transcription of Tnf is significantly increased in BMDMs and BMDCs
• poly(I:C)- and LPS- but not Sendai virus (SeV)-, PGN- or R848-induced secretion of TNF is significantly increased in BMDMs
• poly(I:C)- and LPS- but not SeV-induced transcription of Tnf is markedly increased in MEFs
• reconstitution of TRIM8 markedly inhibits poly(I:C)- and LPS-triggered transcription of Tnf in MEFs
• induction of Tnf mRNA by R848, PGN, or Sendai virus is normal in BMDMs and BMDCs
• after i.p. injection of LPS, mice exhibit significantly higher serum TNF, IL6 and CCL5 levels at 2 h as well as earlier death onset and a higher percentage of lethality within 42 h post-injection relative to wild-type controls
• after oral administration of Salmonella typhimurium, mice exhibit a more severe loss of body weight and septic shock within 6 days post-infection than wild-type controls
• after oral administration of Salmonella typhimurium, mice exhibit earlier death onset and a higher percentage of lethality within 12 days post-infection than wild-type controls

homeostasis/metabolism
• 2 h after i.p. injection of poly(I:C) plus D-galactosamine or LPS, mice exhibit significantly higher serum CCL5 (also known as RANTES) levels than wild-type controls
• 2 h after i.p. injection of poly(I:C) plus D-galactosamine or LPS, mice exhibit significantly higher serum IL6 levels than wild-type controls
• 2 h after i.p. injection of poly(I:C) plus D-galactosamine or LPS, mice exhibit significantly higher serum TNF levels than wild-type controls

hematopoietic system
• poly(I:C)- and LPS- but not Sendai virus (SeV)-, PGN- or R848-induced secretion of IFN-beta, TNF, and IL6 is significantly increased in bone marrow-derived macrophages (BMDMs)





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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory