Phenotypes associated with this allele

• Allele Symbol: Dcaf17^tm1.1Assi
• Allele Name: targeted mutation 1.1, Abdullah Assiri
• Allele ID: MGI:6164306
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dcaf17^tm1.1Assi/Dcaf17^tm1.1Assi	involves: 129S6/SvEvTac * BALB/cJ * C57BL/6NTac	MGI:6196059

Genotype
MGI:6196059

hm1

• Allelic Composition: Dcaf17^tm1.1Assi/Dcaf17^tm1.1Assi
• Genetic Background: involves: 129S6/SvEvTac * BALB/cJ * C57BL/6NTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

reproductive system phenotype ( J:262620 )

♀N • female mice exhibit normal fertility

increased male germ cell apoptosis ( J:262620 )

♂ • with advancing age

asthenozoospermia ( J:262620 )

♂ • with advancing age

abnormal spermatogenesis ( J:262620 )

♂ • severe defects at 42 and 56 dpp

oligozoospermia ( J:262620 )

♂

teratozoospermia ( J:262620 )

♂

abnormal sperm flagellum morphology ( J:262620 )

♂ • ectopically localized flagella

abnormal sperm midpiece morphology ( J:262620 )

♂ • often coils around the head

♂ • disorganized mitochondria trapped inside large cytoplasmic droplets

abnormal sperm head morphology ( J:262620 )

♂ • triangular or cupcake-shaped in some sperm

♂ • oval-shaped head in some sperm

♂ • amorphous in some sperm

♂ • bent heads at the neck in some sperm

abnormal acrosome morphology ( J:262620 )

♂ • with mitochondria aggregating near the deformed nucleus

abnormal acrosome assembly ( J:262620 )

♂ • failure of acrosome cap extension

globozoospermia ( J:262620 )

♂ • mis-localized and deformed acrosome

detached acrosome ( J:262620 )

♂

abnormal sperm nucleus morphology ( J:262620 )

♂ • with defective chromatin condensation and nuclear compaction

abnormal manchette morphology ( J:262620 )

♂ • elongated with abnormal perinuclear ring and severely disorganized microtubule bundles along the posterior surface of the deformed nucleus

abnormal manchette perinuclear ring morphology ( J:262620 )

♂ • abnormal positioning of the perinuclear ring in elongating spermatids

elongated manchette ( J:262620 )

♂

abnormal male meiosis ( J:262620 )

♂ • at 14 dpp some mice exhibit abnormal pachytene spermatocytes

♂ • however, meiotic progression is not affected

male infertility ( J:262620 )

♂ • despite normal mating behavior

cellular

oligozoospermia ( J:262620 )

♂

teratozoospermia ( J:262620 )

♂

abnormal sperm flagellum morphology ( J:262620 )

♂ • ectopically localized flagella

abnormal sperm midpiece morphology ( J:262620 )

♂ • often coils around the head

♂ • disorganized mitochondria trapped inside large cytoplasmic droplets

abnormal sperm head morphology ( J:262620 )

♂ • triangular or cupcake-shaped in some sperm

♂ • oval-shaped head in some sperm

♂ • amorphous in some sperm

♂ • bent heads at the neck in some sperm

abnormal acrosome morphology ( J:262620 )

♂ • with mitochondria aggregating near the deformed nucleus

abnormal acrosome assembly ( J:262620 )

♂ • failure of acrosome cap extension

globozoospermia ( J:262620 )

♂ • mis-localized and deformed acrosome

detached acrosome ( J:262620 )

♂

abnormal sperm nucleus morphology ( J:262620 )

♂ • with defective chromatin condensation and nuclear compaction

abnormal manchette morphology ( J:262620 )

♂ • elongated with abnormal perinuclear ring and severely disorganized microtubule bundles along the posterior surface of the deformed nucleus

abnormal manchette perinuclear ring morphology ( J:262620 )

♂ • abnormal positioning of the perinuclear ring in elongating spermatids

elongated manchette ( J:262620 )

♂

abnormal male meiosis ( J:262620 )

♂ • at 14 dpp some mice exhibit abnormal pachytene spermatocytes

♂ • however, meiotic progression is not affected

increased male germ cell apoptosis ( J:262620 )

♂ • with advancing age

asthenozoospermia ( J:262620 )

♂ • with advancing age