Analysis Tools
behavior/neurological
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• mice performed normally in the rotarod test for motor function and learning
• mice show no differences in a novel object recognition test, suggesting normal cognitive function
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• heterozygous mice reared significantly less than controls
• however, heterozygous mice did not show signs of anxiety based on the time spent in the center of the open field and performance in the elevated plus maze
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• mice did not interact more with a novel stranger than with a familiar mouse
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nervous system
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• reduced total brain volume assayed by ex vivo MRI
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