Analysis Tools
homeostasis/metabolism
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• homozygotes fed a standard chow or ketogenic diet exhibit normal serum free fatty acid levels under ad libitum feeding
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• in vitro enzymatic assays revealed that mitochondrial electron transfer flavoprotein (ETF) activity is ~1.5-fold greater than that in wild-type mitochondria, suggesting increased beta-oxidation capacity
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• following 24 h of fasting, homozygotes maintain a significantly higher core body temperature at 1 h after cold exposure (4 degrees C) than similarly fasted, cold-exposed wild-type controls
• however, no differences in cold tolerance are observed during ad libitum feeding
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• homozygotes fed a ketogenic diet (KD) exhibit increased oxygen consumption relative to KD-fed wild-type controls
• however, no differences in oxygen consumption are observed on a standard chow diet
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• homozygotes fed a ketogenic diet (KD) exhibit increased heat production relative to KD-fed wild-type controls
• however, no differences in heat production are observed on a standard chow diet
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cellular
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• in vitro enzymatic assays revealed that mitochondrial electron transfer flavoprotein (ETF) activity is ~1.5-fold greater than that in wild-type mitochondria, suggesting increased beta-oxidation capacity
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• in vitro enzymatic assays revealed that mitochondrial electron transfer flavoprotein (ETF) activity is ~1.5-fold greater than that in wild-type mitochondria, suggesting increased beta-oxidation capacity
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