Phenotypes associated with this allele

• Allele Symbol: Lgals7^tm1Ijmfp
• Allele Name: targeted mutation 1, Francoise Poirier
• Allele ID: MGI:6188114
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lgals7^tm1Ijmfp/Lgals7^tm1Ijmfp	involves: 129 * C57BL/6 * SJL	MGI:6259425

Genotype
MGI:6259425

hm1

• Allelic Composition: Lgals7^tm1Ijmfp/Lgals7^tm1Ijmfp
• Genetic Background: involves: 129 * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

integument

increased keratinocyte apoptosis ( J:263069 )

• following exposure to UVB, apoptosis in the epidermis occurs quicker and lasts longer than in wild-type mice

decreased keratinocyte migration ( J:263069 )

• during wound healing

increased keratinocyte proliferation ( J:263069 )

• 24 and 48 hours following exposure to UVB

• 48 hours after superficial scratch

increased sensitivity to skin irradiation ( J:263069 )

• following exposure to UVB, mice exhibit increased sunburn cells and increased keratinocyte apoptosis and proliferation compared with wild-type mice

cellular

increased keratinocyte apoptosis ( J:263069 )

• following exposure to UVB, apoptosis in the epidermis occurs quicker and lasts longer than in wild-type mice

decreased keratinocyte migration ( J:263069 )

• during wound healing

increased keratinocyte proliferation ( J:263069 )

• 24 and 48 hours following exposure to UVB

• 48 hours after superficial scratch

homeostasis/metabolism

delayed wound healing ( J:263069 )

• less advanced wound healing 24 hours after superficial scratch with reduced migrating capacity of keratinocytes

• however, closure is complete after 48 hours as in wild-type mice