Phenotypes associated with this allele

• Allele Symbol: Lrrtm1^tm1.1Rmlk
• Allele Name: targeted mutation 1.1, Robert Malenka
• Allele ID: MGI:6188307
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Lrrtm1^tm1.1Rmlk/Lrrtm1^tm1.1Rmlk Lrrtm2^tm1.1Rmlk/Lrrtm2^tm1.1Rmlk	involves: 129P2/OlaHsd * C57BL/6J * FVB/N * SJL	MGI:6188316

Genotype
MGI:6188316

cn1

• Allelic Composition: Lrrtm1^tm1.1Rmlk/Lrrtm1^tm1.1Rmlk; Lrrtm2^tm1.1Rmlk/Lrrtm2^tm1.1Rmlk
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB/N * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

decreased excitatory postsynaptic current amplitude ( J:263004 )

• reduced AMPAR-EPSCs in mice stereotactically-injected cre-expressing lentivirus into the CA1 region of the hippocampus at P21

• however, NMDAR EPSCs are normal

reduced AMPA-mediated synaptic currents ( J:263004 )

• reduced AMPAR-EPSCs and -mEPSCs in mice stereotactically-injected cre-expressing lentivirus into the CA1 region of the hippocampus at P21

• however, NMDAR EPSCs are normal

reduced long-term potentiation ( J:263004 )

• reduced NMDAR-dependent and -independent LTP in mice stereotactically-injected cre-expressing lentivirus into the CA1 region of the hippocampus at P21

abnormal miniature excitatory postsynaptic currents ( J:263004 )

• decreased amplitude of AMPAR-mediated mEPSCs in mice stereotactically-injected cre-expressing lentivirus into the CA1 region of the hippocampus at P21

• however, mEPSC frequency is normal