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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Lag3tm1Daav
targeted mutation 1, Dario AA Vignali
MGI:6188309
Summary 2 genotypes


Genotype
MGI:6188325
cn1
Allelic
Composition		 Lag3tm1Daav/Lag3tm1Daav
Tg(Foxp3-EGFP/cre)1cJbs/0
Genetic
Background		 NOD.Cg-Lag3tm1Daav Tg(Foxp3-EGFP/cre)1cJbs
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lag3tm1Daav mutation (0 available); any Lag3 mutation (43 available)
Tg(Foxp3-EGFP/cre)1cJbs mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal effector T cell number ( J:260063 )
• reduction in the number of conventional effector T cells in islets is due to decreased CD8+ T cell proliferation
abnormal CD8-positive, alpha-beta T cell physiology ( J:260063 )
• decrease in CD8+ T cell proliferation
abnormal interleukin level ( J:260063 )
• CD4+Foxp3- T cells in islets show a reduction in IL-2 production
abnormal tumor necrosis factor level ( J:260063 )
• CD4+FoxP3- and CD8+ T cells in islets show reduced TNF-alpha production
decreased susceptibility to autoimmune diabetes ( J:260063 )
• females exhibit a delayed onset of autoimmune diabetes and decreased diabetes incidence (48% vs 84% in controls) by 30 weeks of age
• males are completely protected from developing autoimmune diabetes
• both males and females show a reduction in degree of insulitis at 10 weeks of age
• mice exhibit reduced lymphocyte infiltration into islets, with reduced numbers of CD4+FoxP3- and CD8+ T cells

hematopoietic system
abnormal effector T cell number ( J:260063 )
• reduction in the number of conventional effector T cells in islets is due to decreased CD8+ T cell proliferation
abnormal CD8-positive, alpha-beta T cell physiology ( J:260063 )
• decrease in CD8+ T cell proliferation

homeostasis/metabolism
abnormal interleukin level ( J:260063 )
• CD4+Foxp3- T cells in islets show a reduction in IL-2 production
abnormal tumor necrosis factor level ( J:260063 )
• CD4+FoxP3- and CD8+ T cells in islets show reduced TNF-alpha production




Genotype
MGI:6188326
cn2
Allelic
Composition		 Lag3tm1Daav/Lag3+
Tg(Foxp3-EGFP/cre)1cJbs/0
Genetic
Background		 NOD.Cg-Lag3tm1Daav Tg(Foxp3-EGFP/cre)1cJbs
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lag3tm1Daav mutation (0 available); any Lag3 mutation (43 available)
Tg(Foxp3-EGFP/cre)1cJbs mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased susceptibility to autoimmune diabetes ( J:260063 )
• females exhibit a diabetes incidence of 60% compared to 80-84% in controls




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory