About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Lag3tm1Daav
targeted mutation 1, Dario AA Vignali
MGI:6188309
Summary 2 genotypes


Genotype
MGI:6188325
cn1
Allelic
Composition		 Lag3tm1Daav/Lag3tm1Daav
Tg(Foxp3-EGFP/cre)1cJbs/0
Genetic
Background		 NOD.Cg-Lag3tm1Daav Tg(Foxp3-EGFP/cre)1cJbs
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lag3tm1Daav mutation (0 available); any Lag3 mutation (43 available)
Tg(Foxp3-EGFP/cre)1cJbs mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal effector T cell number ( J:260063 )
• reduction in the number of conventional effector T cells in islets is due to decreased CD8+ T cell proliferation
abnormal CD8-positive, alpha-beta T cell physiology ( J:260063 )
• decrease in CD8+ T cell proliferation
abnormal interleukin level ( J:260063 )
• CD4+Foxp3- T cells in islets show a reduction in IL-2 production
abnormal tumor necrosis factor level ( J:260063 )
• CD4+FoxP3- and CD8+ T cells in islets show reduced TNF-alpha production
decreased susceptibility to autoimmune diabetes ( J:260063 )
• females exhibit a delayed onset of autoimmune diabetes and decreased diabetes incidence (48% vs 84% in controls) by 30 weeks of age
• males are completely protected from developing autoimmune diabetes
• both males and females show a reduction in degree of insulitis at 10 weeks of age
• mice exhibit reduced lymphocyte infiltration into islets, with reduced numbers of CD4+FoxP3- and CD8+ T cells

hematopoietic system
abnormal effector T cell number ( J:260063 )
• reduction in the number of conventional effector T cells in islets is due to decreased CD8+ T cell proliferation
abnormal CD8-positive, alpha-beta T cell physiology ( J:260063 )
• decrease in CD8+ T cell proliferation

homeostasis/metabolism
abnormal interleukin level ( J:260063 )
• CD4+Foxp3- T cells in islets show a reduction in IL-2 production
abnormal tumor necrosis factor level ( J:260063 )
• CD4+FoxP3- and CD8+ T cells in islets show reduced TNF-alpha production




Genotype
MGI:6188326
cn2
Allelic
Composition		 Lag3tm1Daav/Lag3+
Tg(Foxp3-EGFP/cre)1cJbs/0
Genetic
Background		 NOD.Cg-Lag3tm1Daav Tg(Foxp3-EGFP/cre)1cJbs
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lag3tm1Daav mutation (0 available); any Lag3 mutation (43 available)
Tg(Foxp3-EGFP/cre)1cJbs mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased susceptibility to autoimmune diabetes ( J:260063 )
• females exhibit a diabetes incidence of 60% compared to 80-84% in controls




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory