Phenotypes associated with this allele

• Allele Symbol: Svep1^{tm1c(EUCOMM)Hmgu}
• Allele Name: targeted mutation 1c, Helmholtz Zentrum Muenchen GmbH
• Allele ID: MGI:6188643
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Apoe^tm1Unc/Apoe^tm1Unc Svep1^tm1c(EUCOMM)Hmgu/Svep1^tm1c(EUCOMM)Hmgu Tg(Myh11-icre/ERT2)1Soff/0	involves: 129P2/OlaHsd * C57BL/6N * FVB/N	MGI:7516351

Genotype
MGI:7516351

cn1

• Allelic Composition: Apoe^tm1Unc/Apoe^tm1Unc; Svep1^{tm1c(EUCOMM)Hmgu}/Svep1^{tm1c(EUCOMM)Hmgu}; Tg(Myh11-icre/ERT2)1Soff/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6N * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal artery morphology ( J:304349 )

• reduced atherosclerotic plaque burden in whole aorta and aortic arch and root after 8 and 16 weeks of HFD feeding

• reduced macrophage invasion of aortic atheromas and reduced necrotic core area after 8 and 16 weeks of HFD feeding

• increased atherosclerotic plaque collagen content after 16 weeks of HFD feeding

growth/size/body

growth/size/body region phenotype ( J:304349 )

N • normal body weight after 8 and 16 weeks of HFD feeding

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:304349 )

N • normal plasma total cholesterol, triglycerides and glucose levels after 8 weeks of HFD feeding

N • normal plasma total cholesterol and glucose levels after 16 weeks of HFD feeding