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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Scyl3tm1.1Spel
targeted mutation 1.1, Stephane Pelletier
MGI:6188894
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Scyl3tm1.1Spel/Scyl3tm1.1Spel involves: 129S6/SvEvTac * C57BL/6J MGI:6188974
cx2
 		Scyl1tm1.1Spel/Scyl1tm1.1Spel
Scyl3tm1.1Spel/Scyl3tm1.1Spel 		involves: 129S6/SvEvTac * C57BL/6J MGI:6188975


Genotype
MGI:6188974
hm1
Allelic
Composition		 Scyl3tm1.1Spel/Scyl3tm1.1Spel
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Scyl3tm1.1Spel mutation (0 available); any Scyl3 mutation (32 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
muscle
abnormal skeletal muscle fiber morphology ( J:262629 )
• angulated muscle fibers in rectus femoris

behavior/neurological
behavior/neurological phenotype ( J:262629 )
N
• mice exhibit normal gripe strength in a mesh test at 4 and 8 weeks of age

immune system
immune system phenotype ( J:262629 )
N
• mice exhibit normal T- and B-cell development and homeostasis

cellular
cellular phenotype ( J:262629 )
N
• mouse embryonic fibroblasts exhibit normal migration in vitro and proliferation




Genotype
MGI:6188975
cx2
Allelic
Composition		 Scyl1tm1.1Spel/Scyl1tm1.1Spel
Scyl3tm1.1Spel/Scyl3tm1.1Spel
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Scyl1tm1.1Spel mutation (0 available); any Scyl1 mutation (21 available)
Scyl3tm1.1Spel mutation (0 available); any Scyl3 mutation (32 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
gliosis ( J:262629 )
• in the ventral horn of the spinal cord to a greater extent than in Scyl1tm1.1Spel single homozygotes
decreased motor neuron number ( J:262629 )
• of large motor neurons in the ventral horn of the spinal cord at 4 weeks compared with Scyl1tm1.1Spel single homozygotes
• at 8 weeks compared with wild-type mice
motor neuron degeneration ( J:262629 )
• at 4 and 8 weeks with Tardbp pathology
abnormal sciatic nerve morphology ( J:262629 )
• reduced number of large caliber axons and total number of myelinated fibers in the sciatic nerve at 4 weeks of age
• at 8 weeks compared with wild-type mice
abnormal myelination ( J:262629 )
• reduced total number of myelinated fibers in the sciatic nerve at 4 weeks of age
• at 8 weeks compared with wild-type mice

growth/size/body
decreased body size ( J:262629 )
• compared with either single homozygotes
decreased body height ( J:262629 )
• at 8 weeks compared with Scyl1tm1.1Spel single homozygotes
postnatal growth retardation ( J:262629 )
• by 3 weeks of age

behavior/neurological
decreased grip strength ( J:262629 )
• progressive motor dysfunction leading to a paralysis that is worse than in Scyl1tm1.1Spel single homozygotes at the same age
paralysis ( J:262629 )
• progressive motor dysfunction leading to a paralysis that is worse than in Scyl1tm1.1Spel single homozygotes at the same age

muscle
decreased skeletal muscle fiber diameter ( J:262629 )
• reduced cross-sectional area in rectus femoris and bicep brachii at 4 and 8 weeks of age that is more severe at 4 weeks than in Scyl1tm1.1Spel single homozygotes
• at 8 weeks compared with wild-type mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory