Phenotypes associated with this allele

• Allele Symbol: H2-Ob^em1Tvg
• Allele Name: endonuclease-mediated mutation 1, Tatyana Golovkina
• Allele ID: MGI:6189528
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	H2-Ob^em1Tvg/H2-Ob^em1Tvg	C57BL/6J-H2-Ob^em1Tvg/Tvg	MGI:6189532

Genotype
MGI:6189532

hm1

• Allelic Composition: H2-Ob^em1Tvg/H2-Ob^em1Tvg
• Genetic Background: C57BL/6J-H2-Ob^em1Tvg/Tvg

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:254532 )

N • homozygotes have normal numbers of antigen presenting cells by FACS analysis for ITGAX, CD8a, PTPRC, CD19, and MHC Class II

defective assembly of class II molecules ( J:254532 )

• FACS analysis of B cells from homozygotes shows fewer MHC Class II-CLIP complexes although the overall level of MHC Class II is normal

decreased susceptibility to Retroviridae infection ( J:254532 )

• homozygotes produce MMTV neutralizing antibodies and clear MMTV infection similar to that seen in I/LnJ inbred mice, despite having a different MHC haplotype