Phenotypes associated with this allele

• Allele Symbol: Adamts3^tm1.2Itl
• Allele Name: targeted mutation 1.2, inGenious Targeting Laboratory
• Allele ID: MGI:6189557
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Adamts3^tm1.2Itl/Adamts3^tm1.2Itl	involves: BALB/cJ * C57BL/6NTac * SJL	MGI:6189565

Genotype
MGI:6189565

hm1

• Allelic Composition: Adamts3^tm1.2Itl/Adamts3^tm1.2Itl
• Genetic Background: involves: BALB/cJ * C57BL/6NTac * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:245044 )

• after E15

liver/biliary system

increased hepatocyte apoptosis ( J:245044 )

• at E13.4 and E14.5

small liver ( J:245044 )

• at E14.5

liver degeneration ( J:245044 )

• beginning at E13.5 with swollen cells on ventral areas spreading at E14.5

immune system

abnormal lymphangiogenesis ( J:245044 )

absent lymphatic vessels ( J:245044 )

embryo

abnormal placenta labyrinth morphology ( J:245044 )

• reduced specific surface

abnormal placenta fetal blood space morphology ( J:245044 )

• increased number of fetal blood vessels full of nucleated red blood cells due to narrowness

integument

skin edema ( J:245044 )

• in the dorsal skin at E13.5

• at E14.5

pallor ( J:245044 )

• at E14.5

hematopoietic system

abnormal erythrocyte morphology ( J:245044 )

• increased ratio of nucleated to nonnucleated red blood cells at E14.5

homeostasis/metabolism

skin edema ( J:245044 )

• in the dorsal skin at E13.5

• at E14.5

skeleton

skeleton phenotype ( J:245044 )

N • mice exhibit normal type II collagen and cartilage formation

cellular

increased hepatocyte apoptosis ( J:245044 )

• at E13.4 and E14.5