Phenotypes associated with this allele

• Allele Symbol: Lrrtm3^tm1Msa
• Allele Name: targeted mutation 1, Matti S Airaksinen
• Allele ID: MGI:6191636
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lrrtm3^tm1Msa/Lrrtm3^tm1Msa	B6JHsd.129-Lrrtm3^tm1Msa	MGI:6197027
hm2	Lrrtm3^tm1Msa/Lrrtm3^tm1Msa	involves: 129S1/Sv * 129X1/SvJ	MGI:6197065
cx3	Lrrtm3^tm1Msa/Lrrtm3^tm1Msa Tg(APPswe,PSEN1dE9)85Dbo/0	involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6JHsd	MGI:6197029

Genotype
MGI:6197027

hm1

• Allelic Composition: Lrrtm3^tm1Msa/Lrrtm3^tm1Msa
• Genetic Background: B6JHsd.129-Lrrtm3^tm1Msa

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

normal phenotype

no abnormal phenotype detected ( J:262456 )

• mice are viable and exhibit no obvious physical abnormalities

Genotype
MGI:6197065

hm2

• Allelic Composition: Lrrtm3^tm1Msa/Lrrtm3^tm1Msa
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

nervous system

decreased dendritic spine density ( J:263400 )

• in dentate gyrus granule neurons

• modestly reduced of the number of dendritic spines of asymmetric/excitatory synapses in middle molecular layer at P14

• however, excitatory synapse density is normal in CA1 pyramidal neurons and the number of GABA+ presynaptic boutons is normal

abnormal action potential ( J:263400 )

• lower firing rate of dentate granule neurons

• however, CA1 pyramidal neurons exhibit normal firing rates

abnormal CNS synaptic transmission ( J:263400 )

• small decrease in evoked excitatory synaptic transmission

• however, maximal response is normal

decreased excitatory postsynaptic current amplitude ( J:263400 )

• in dentate gyrus granule cells

abnormal miniature excitatory postsynaptic currents ( J:263400 )

• reduced amplitude with increased frequency in dentate gyrus granule cells

• however, miniature miniature inhibitory postsynaptic current frequency and amplitude are normal

abnormal synaptic depression ( J:263400 )

• faster depression of evoked EPSC amplitude

decreased paired-pulse facilitation ( J:263400 )

Genotype
MGI:6197029

cx3

• Allelic Composition: Lrrtm3^tm1Msa/Lrrtm3^tm1Msa; Tg(APPswe,PSEN1dE9)85Dbo/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6JHsd

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:262456 )

N • mice exhibit normal amyloid-beta production