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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Stxbp5ltm1.1Aljg
targeted mutation 1.1, Alexander J Groffen
MGI:6191659
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Stxbp5ltm1.1Aljg/Stxbp5ltm1.1Aljg B6.Cg-Stxbp5ltm1.1Aljg MGI:6197484
hm2
Stxbp5ltm1.1Aljg/Stxbp5ltm1.1Aljg involves: C57BL/6J MGI:6197485


Genotype
MGI:6197484
hm1
Allelic
Composition
Stxbp5ltm1.1Aljg/Stxbp5ltm1.1Aljg
Genetic
Background
B6.Cg-Stxbp5ltm1.1Aljg
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stxbp5ltm1.1Aljg mutation (0 available); any Stxbp5l mutation (60 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• Background Sensitivity: mice on a congenic C57BL/6J background exhibit normal embryonic and postnatal survival unlike mice on a mixed background




Genotype
MGI:6197485
hm2
Allelic
Composition
Stxbp5ltm1.1Aljg/Stxbp5ltm1.1Aljg
Genetic
Background
involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stxbp5ltm1.1Aljg mutation (0 available); any Stxbp5l mutation (60 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• Background Sensitivity: some mice on a mixed background die between E18 and 3 weeks of age unlike mice on a congenic C57BL/6J background
• however, no additional loss is observed after P21

nervous system
• degeneration of the central nervous system at E18
• however, neuronal morphology is normal
• however, acoustic startle response is normal
• at 40 Hz, neuromuscular junctions exhibit a greater decrease in EPP amplitude compared to in wild-type mice
• repetitive stimulation reduces EPP amplitudes
• increased at neuromuscular junctions
• however, mEPP amplitude and kinetics are normal at low rates of stimulation and neurotransmitter release in hippocampal synapses is normal
• at neuromuscular junctions

behavior/neurological
• however, motor learning on a rotarod is normal
• with a reduction in the number of reaches when lowered to the edge of a grid
• less motile at E18

cardiovascular system
• head or abdominal at E18

growth/size/body
• slightly in one set of animals

homeostasis/metabolism

integument
• white appearance at E18





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory