mortality/aging
N |
• Background Sensitivity: mice on a congenic C57BL/6J background exhibit normal embryonic and postnatal survival unlike mice on a mixed background
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Allele Symbol Allele Name Allele ID |
Stxbp5ltm1.1Aljg targeted mutation 1.1, Alexander J Groffen MGI:6191659 |
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Summary |
2 genotypes
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
N |
• Background Sensitivity: mice on a congenic C57BL/6J background exhibit normal embryonic and postnatal survival unlike mice on a mixed background
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• Background Sensitivity: some mice on a mixed background die between E18 and 3 weeks of age unlike mice on a congenic C57BL/6J background
• however, no additional loss is observed after P21
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• degeneration of the central nervous system at E18
• however, neuronal morphology is normal
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• however, acoustic startle response is normal
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• at 40 Hz, neuromuscular junctions exhibit a greater decrease in EPP amplitude compared to in wild-type mice
• repetitive stimulation reduces EPP amplitudes
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• increased at neuromuscular junctions
• however, mEPP amplitude and kinetics are normal at low rates of stimulation and neurotransmitter release in hippocampal synapses is normal
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• at neuromuscular junctions
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• however, motor learning on a rotarod is normal
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• with a reduction in the number of reaches when lowered to the edge of a grid
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• less motile at E18
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• head or abdominal at E18
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• slightly in one set of animals
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• at E18
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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