Phenotypes associated with this allele

• Allele Symbol: Dlgap2^tm1.1Ssfg
• Allele Name: targeted mutation 1.1, Susan Shur-Fen Gau
• Allele ID: MGI:6191669
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dlgap2^tm1.1Ssfg/Dlgap2^tm1.1Ssfg	B6.129S1-Dlgap2^tm1.1Ssfg	MGI:6191729

Genotype
MGI:6191729

hm1

• Allelic Composition: Dlgap2^tm1.1Ssfg/Dlgap2^tm1.1Ssfg
• Genetic Background: B6.129S1-Dlgap2^tm1.1Ssfg

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

decreased dendritic spine density ( J:263415 )

• in the orbitofrontal cortex

abnormal synapse morphology ( J:263415 )

• severe synaptopathies within the cerebral cortex

abnormal postsynaptic density morphology ( J:263415 )

• reduced length and thickness of postsynaptic density in the orbitofrontal cortex

abnormal neuron physiology ( J:263415 )

• enhanced paired-pulse ratio

abnormal miniature excitatory postsynaptic currents ( J:263415 )

• reduced peak amplitude with a trend toward reduced frequency

behavior/neurological

abnormal spatial learning ( J:263415 )

• impaired reverse learning in a water T maze

increased aggression towards mice ( J:263415 )

• shorter latency to attack in an resident-intruder test with increased duration and frequency of aggressive behaviors

induced hyperactivity ( J:263415 )

• novelty-induced in the first 5 minutes of an open-field test

abnormal social investigation ( J:263415 )

• enhanced social approach

• however, social recognition is normal