All Phenotypes Rem2<tm1c(EUCOMM)Hmgu> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Rem2^{tm1c(EUCOMM)Hmgu}
targeted mutation 1c, Helmholtz Zentrum Muenchen GmbH
MGI:6192081

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Rem2^{tm1c(EUCOMM)Hmgu}/Rem2^{tm1c(EUCOMM)Hmgu}	involves: 129S4/SvJaeSor * C57BL/6N	MGI:6192635
cn2	Rem2^{tm1c(EUCOMM)Hmgu}/Rem2^{tm1c(EUCOMM)Hmgu} Pvalb^tm1(cre)Arbr/Pvalb⁺	involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6N	MGI:6192626
cn3	Rem2^{tm1c(EUCOMM)Hmgu}/Rem2^{tm1c(EUCOMM)Hmgu} Emx1^tm1(cre)Krj/Emx1⁺	involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6N	MGI:6192624
cn4	Rem2^{tm1c(EUCOMM)Hmgu}/Rem2^{tm1c(EUCOMM)Hmgu} Gt(ROSA)26Sor^{tm9(CAG-tdTomato)Hze}/Gt(ROSA)26Sor⁺	involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6N * C57BL/6NCrl	MGI:6192637
cn5	Rem2^{tm1c(EUCOMM)Hmgu}/Rem2^{tm1c(EUCOMM)Hmgu} Vip^tm1(cre)Zjh/Vip⁺	involves: 129S4/SvJaeSor * C57BL/6N	MGI:6192628

Allelic Composition	Rem2^{tm1c(EUCOMM)Hmgu}/Rem2^{tm1c(EUCOMM)Hmgu}
Genetic Background	involves: 129S4/SvJaeSor * C57BL/6N
Cell Lines	HEPD0760_4_D07

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rem2^{tm1c(EUCOMM)Hmgu} mutation (0 available); any Rem2 mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal action potential ( J:263600 )

• mice injected with cre-expressing virus at P20 exhibit increased spontaneous firing rates in the layer 2/3 pyramidal neurons compared with control mice

• however, mice injected with cre-expressing virus and subjected to 2 days of monocular deprivation exhibit normal firing rates

abnormal CNS synaptic transmission ( J:263600 )

• 4 or 10-12 days after injection with cre-expressing virus at P18-20 into a few dozen neurons, intrinsic excitability is response to current is increased compared to in control mice

abnormal miniature excitatory postsynaptic currents ( J:263600 )

• 10-12 days after sparse injection with cre-expressing virus, mEPSC frequency, but not amplitude, is decreased compared to in control mice

• however, response 4 days after injection is normal

Allelic Composition	Rem2^{tm1c(EUCOMM)Hmgu}/Rem2^{tm1c(EUCOMM)Hmgu} Pvalb^tm1(cre)Arbr/Pvalb⁺
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pvalb^tm1(cre)Arbr mutation (5 available); any Pvalb mutation (29 available)
Rem2^{tm1c(EUCOMM)Hmgu} mutation (0 available); any Rem2 mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

vision/eye phenotype ( J:263600 )

N	• mice subjected to monocular deprivation exhibit normal ocular dominance plasticity

Allelic Composition	Rem2^{tm1c(EUCOMM)Hmgu}/Rem2^{tm1c(EUCOMM)Hmgu} Emx1^tm1(cre)Krj/Emx1⁺
Genetic Background	involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6N
Cell Lines	HEPD0760_4_D07

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Emx1^tm1(cre)Krj mutation (2 available); any Emx1 mutation (34 available)
Rem2^{tm1c(EUCOMM)Hmgu} mutation (0 available); any Rem2 mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal visual cortex morphology ( J:263600 )

• mice subjected to monocular deprivation exhibit reduced ocular dominance plasticity measured by optical imaging of intrinsic signals compared with control mice but to a lesser extent than in knock-out mice

Allelic Composition	Rem2^{tm1c(EUCOMM)Hmgu}/Rem2^{tm1c(EUCOMM)Hmgu} Gt(ROSA)26Sor^{tm9(CAG-tdTomato)Hze}/Gt(ROSA)26Sor⁺
Genetic Background	involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6N * C57BL/6NCrl
Cell Lines	HEPD0760_4_D07

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm9(CAG-tdTomato)Hze} mutation (4 available); any Gt(ROSA)26Sor mutation (993 available)
Rem2^{tm1c(EUCOMM)Hmgu} mutation (0 available); any Rem2 mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

decreased dendritic spine density ( J:263600 )

• 10 days after sparse injection with cre-expressing virus, mice exhibit decreased spine density, spine head width and spine neck length compared with control mice

Allelic Composition	Rem2^{tm1c(EUCOMM)Hmgu}/Rem2^{tm1c(EUCOMM)Hmgu} Vip^tm1(cre)Zjh/Vip⁺
Genetic Background	involves: 129S4/SvJaeSor * C57BL/6N
Cell Lines	HEPD0760_4_D07

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rem2^{tm1c(EUCOMM)Hmgu} mutation (0 available); any Rem2 mutation (18 available)
Vip^tm1(cre)Zjh mutation (3 available); any Vip mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

vision/eye phenotype ( J:263600 )

N	• mice subjected to monocular deprivation exhibit normal ocular dominance plasticity

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