All Phenotypes Tg(Erbb2*)#Maed MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tg(Erbb2*)#Maed
transgene insertion, Shin Maeda
MGI:6192630

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Kras^tm4Tyj/Kras⁺ Tg(Erbb2*)#Maed/0 Ptf1a^{tm1.1(cre)Cvw}/Ptf1a⁺	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6J	MGI:6192639
cn2	Tg(Erbb2*)#Maed/0 Ptf1a^{tm1.1(cre)Cvw}/Ptf1a⁺	involves: 129S/Sv * 129X1/SvJ * C57BL/6J	MGI:6192638
cn3	Tg(Erbb2*)#Maed/0 Tg(Foxa3-cre)1Khk/0	involves: C57BL/6 * C57BL/6J * DBA	MGI:6192631

Allelic Composition	Kras^tm4Tyj/Kras⁺ Tg(Erbb2*)#Maed/0 Ptf1a^{tm1.1(cre)Cvw}/Ptf1a⁺
Genetic Background	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kras^tm4Tyj mutation (9 available); any Kras mutation (84 available)
Ptf1a^{tm1.1(cre)Cvw} mutation (1 available); any Ptf1a mutation (31 available)
Tg(Erbb2*)#Maed mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

digestive/alimentary system

abnormal pancreatic acinar cell morphology ( J:262746 )

• 6 month old mice exhibit severe acinar cell loss

endocrine/exocrine glands

abnormal pancreatic acinar cell morphology ( J:262746 )

• 6 month old mice exhibit severe acinar cell loss

increased pancreatic intraepithelial neoplasia incidence ( J:262746 )

• mice show accelerated pancreatic intraepithelial neoplasia (PanIN) lesions with severe acinar cell loss, with majority of lesions being PanIN-1 but having some PanIN-2 and -3 lesions

neoplasm

increased pancreatic intraepithelial neoplasia incidence ( J:262746 )

• mice show accelerated pancreatic intraepithelial neoplasia (PanIN) lesions with severe acinar cell loss, with majority of lesions being PanIN-1 but having some PanIN-2 and -3 lesions

Allelic Composition	Tg(Erbb2*)#Maed/0 Ptf1a^{tm1.1(cre)Cvw}/Ptf1a⁺
Genetic Background	involves: 129S/Sv * 129X1/SvJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptf1a^{tm1.1(cre)Cvw} mutation (1 available); any Ptf1a mutation (31 available)
Tg(Erbb2*)#Maed mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:262746 )

N	• mice show almost no phenotypes in pancreas at 6 months of age

Allelic Composition	Tg(Erbb2*)#Maed/0 Tg(Foxa3-cre)1Khk/0
Genetic Background	involves: C57BL/6 * C57BL/6J * DBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Erbb2*)#Maed mutation (0 available)
Tg(Foxa3-cre)1Khk mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:262746 )

• most mice die within 10 weeks after birth

neoplasm

increased pancreas tumor incidence ( J:262746 )

• papillary epithelial cells show dysplasia of low- to high-grades, resembling human intraductal papillary mucinous neoplasm with focal high-grade dysplasia

digestive/alimentary system

abnormal pancreatic acinar cell morphology ( J:262746 )

• loss of acinar cells in the pancreatic parenchyma, broad cystic changes, and elevated papillary lesions

endocrine/exocrine glands

abnormal pancreas morphology ( J:262746 )

• mice develop cystic lesions exhibiting papillary proliferation in almost all pancreatic tissue at 8 weeks of age

abnormal pancreatic acinar cell morphology ( J:262746 )

• loss of acinar cells in the pancreatic parenchyma, broad cystic changes, and elevated papillary lesions

increased pancreas tumor incidence ( J:262746 )

• papillary epithelial cells show dysplasia of low- to high-grades, resembling human intraductal papillary mucinous neoplasm with focal high-grade dysplasia

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
benign neoplasm		DOID:0060072		J:262746

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