Phenotypes associated with this allele

• Allele Symbol: Tg(RNU6-1-RNAi:Cdk5)#Chad
• Allele Name: transgene insertion, Changsheng Dong
• Allele ID: MGI:6193754
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(RNU6-1-RNAi:Cdk5)#Chad/0	C57BL/6J-Tg(RNU6-1-RNAi:Cdk5)#Chad	MGI:6220672

Genotype
MGI:6220672

tg1

• Allelic Composition: Tg(RNU6-1-RNAi:Cdk5)#Chad/0
• Genetic Background: C57BL/6J-Tg(RNU6-1-RNAi:Cdk5)#Chad

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

integument

abnormal hair follicle melanin granule distribution ( J:255707 )

• transgenic mice show localized distribution of melanin to the upper dermal papilla in the hair follicles

• expression of membrane-associated transporter protein (MATP) in skin is reduced relative to that in wild-type controls

diluted coat color ( J:255707 )

• at 4 weeks of age, transgenic mice exhibit a light brown coat color, whereas non-transgenic mice are black

alopecia ( J:255707 )

• at ~8 weeks, transgenic mice start to lose hair, unlike wild-type controls

abnormal hair follicle dermal papilla morphology ( J:255707 )

• melanin is localized to melanogenic melanocytes in the upper dermal papilla

enlarged spinous cells ( J:255707 )

thick epidermis stratum spinosum ( J:255707 )

thick epidermis ( J:255707 )

• at 6 months of age, the epidermis is thickened due to increased stratification, esp.in the stratum spinosum; cells of all strata are enlarged

• keratin 10 (K10) protein levels in skin are significantly lower than those in wild-type controls

skin lesions ( J:255707 )

• at ~8 weeks, transgenic mice exhibit plaques of red skin, unlike wild-type controls

abnormal skin condition ( J:255707 )

• at ~8 weeks, transgenic mice start to exhibit abnormal skin conditions

pigmentation

abnormal hair follicle melanin granule distribution ( J:255707 )

• transgenic mice show localized distribution of melanin to the upper dermal papilla in the hair follicles

• expression of membrane-associated transporter protein (MATP) in skin is reduced relative to that in wild-type controls

diluted coat color ( J:255707 )

• at 4 weeks of age, transgenic mice exhibit a light brown coat color, whereas non-transgenic mice are black

abnormal melanogenesis ( J:255707 )

• spectrophotometric analysis of alkali-soluble melanins in the hair revealed a significant reduction in melanin content relative to wild-type controls

• a significant reduction in the expression levels of MITF, TYRP1, TYRP2, PAX3, MC1R, PMEL (gp100) and MC4R proteins is noted in skin

abnormal melanosome transport ( J:255707 )

• transgenic mice show an impaired transportation system of melanins