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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Myh6-Prkaca)33Eno
transgene insertion 33, Eric N Olson
MGI:6193912
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
tg1
Tg(Myh6-Prkaca)33Eno/0 Not Specified MGI:6193916


Genotype
MGI:6193916
tg1
Allelic
Composition
Tg(Myh6-Prkaca)33Eno/0
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice display higher mortality, with mice dying starting after 5 weeks of age and showing about 70% survival at 30 weeks of age

cardiovascular system
• cardiomyocytes are enlarged and cardiomyocyte nuclei are enlarged
• mice develop enlarged hearts by 13 weeks of age
• cardiomyocytes are enlarged and expression of hypertrophic marker genes are elevated
• ventricular walls are only moderately thicker at 10 weeks of age
• dilated hearts show mild fibrosis
• mice develop dilated cardiomyopathy by 13 weeks of age
• however, hearts are normal at 4-8 weeks of age
• mice exhibit symptoms indicative of congestive heart failure

homeostasis/metabolism
• atria frequently contain organized thrombi
• in severe cases, mice develop edema

muscle
• cardiomyocytes are enlarged and cardiomyocyte nuclei are enlarged
• mice develop dilated cardiomyopathy by 13 weeks of age
• however, hearts are normal at 4-8 weeks of age

growth/size/body
• mice develop enlarged hearts by 13 weeks of age
• cardiomyocytes are enlarged and expression of hypertrophic marker genes are elevated

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
dilated cardiomyopathy DOID:12930 OMIM:PS115200
J:263774





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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory