mortality/aging
• mice display higher mortality, with mice dying starting after 5 weeks of age and showing about 70% survival at 30 weeks of age
|
cardiovascular system
• cardiomyocytes are enlarged and cardiomyocyte nuclei are enlarged
|
• mice develop enlarged hearts by 13 weeks of age
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• cardiomyocytes are enlarged and expression of hypertrophic marker genes are elevated
|
• ventricular walls are only moderately thicker at 10 weeks of age
|
• dilated hearts show mild fibrosis
|
• mice develop dilated cardiomyopathy by 13 weeks of age
• however, hearts are normal at 4-8 weeks of age
|
• mice exhibit symptoms indicative of congestive heart failure
|
homeostasis/metabolism
• atria frequently contain organized thrombi
|
muscle
• cardiomyocytes are enlarged and cardiomyocyte nuclei are enlarged
|
• mice develop dilated cardiomyopathy by 13 weeks of age
• however, hearts are normal at 4-8 weeks of age
|
growth/size/body
• mice develop enlarged hearts by 13 weeks of age
|
• cardiomyocytes are enlarged and expression of hypertrophic marker genes are elevated
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
dilated cardiomyopathy | DOID:12930 |
OMIM:PS115200 |
J:263774 |