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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Myh6-Prkaca)2Eno
transgene insertion 2, Eric N Olson
MGI:6193913
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
tg1
Tg(Myh6-Prkaca)2Eno/0 Not Specified MGI:6193917


Genotype
MGI:6193917
tg1
Allelic
Composition
Tg(Myh6-Prkaca)2Eno/0
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice display higher mortality, with no mice surviving past 20 weeks

cardiovascular system
• cardiomyocytes are enlarged and cardiomyocyte nuclei are enlarged
• mice develop enlarged hearts
• however, hearts are normal at 4-8 weeks of age
• cardiomyocytes are enlarged and expression of hypertrophic marker genes are elevated
• ventricular walls are only moderately thicker at 10 weeks of age
• dilated hearts show mild fibrosis
• mice develop dilated cardiomyopathy
• fractional shortening is reduced, indicating contractile dysfunction
• echocardiography at 8 weeks of age indicates increased systolic dimensions and a tendency towards increased diastolic diameters of the left-ventricular chamber
• ECG-analysis indicates atrial fibrillation in 5 of 8 mice
• mice frequently exhibit premature ventricular beats
• in a severe case, spontaneous pauses in contraction lasting longer than 5 seconds are seen, most likely due to sinoatrial block
• mice exhibit symptoms indicative of congestive heart failure

homeostasis/metabolism
• atria frequently contain organized thrombi
• severe anasarca in severe cases

muscle
• cardiomyocytes are enlarged and cardiomyocyte nuclei are enlarged
• mice develop dilated cardiomyopathy
• fractional shortening is reduced, indicating contractile dysfunction

growth/size/body
• mice develop enlarged hearts
• however, hearts are normal at 4-8 weeks of age
• cardiomyocytes are enlarged and expression of hypertrophic marker genes are elevated

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
dilated cardiomyopathy DOID:12930 OMIM:PS115200
J:263774





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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory