Analysis Tools
cardiovascular system
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• hearts of both young and old mice exhibit increased mitochondria
• however, sarcomeric structure in the myocardium at 6 months of age is normal
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• mice aged over 13 months exhibit hypertrophy of both anterior and posterior wall and an approximate 1.6-fold higher left ventricle mass indicating that cardiac hypertrophy develops in senescent mice
• hypertrophic phenotype in old mice shows a concentric pattern manifested by reduced left ventricle diameter in systole and diastole
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• mild fibrosis is seen at 8 months of age which severely increases in 15 month old mice
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• the ejection fraction is higher in older mice, indicating that hypertrophy does not compromise systolic function
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• 6 month old mice show a prolonged isovolumic relaxation time (Tau) and a tendency for slower rate of pressure decline, indicating diastolic function alterations
• mice show mild signs of diastolic disturbance with lower E/A ratios at 6 months of age
• however, mice show preserved systolic function at 6 months of age
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• echocardiography with pulse wave Doppler shows diastolic disturbance with reduced E/A transmitral velocities ratio in 6 month old mice
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• skinned papillary muscles from 5-6 month old mice show reduced maximal tension and slower muscle relaxation rates
• skinned papillary muscle shows increased levels of passive tension suggesting an increase in muscle stiffness in the myocardium
• myofibril myosin cross-bridges show an increase in the rate of biding to thin filaments and a faster rate of power stroke and decrease in the rate of transition to a rigor-like state, suggesting that cross-bridges stay attached longer to actin and relaxation takes a longer time to be completed
• myosin ATPase activity is higher, indicating increased energy consumption
• in in vitro motility assay, myosin produces higher actin sliding velocity under zero load but velocity decreases with applied load
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• echocardiography of old mice indicates hypertrophic cardiomyopathy
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cellular
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• hearts of both young and old mice exhibit increased mitochondria
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muscle
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• the ejection fraction is higher in older mice, indicating that hypertrophy does not compromise systolic function
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|
• 6 month old mice show a prolonged isovolumic relaxation time (Tau) and a tendency for slower rate of pressure decline, indicating diastolic function alterations
• mice show mild signs of diastolic disturbance with lower E/A ratios at 6 months of age
• however, mice show preserved systolic function at 6 months of age
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• echocardiography of old mice indicates hypertrophic cardiomyopathy
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growth/size/body
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• mice aged over 13 months exhibit hypertrophy of both anterior and posterior wall and an approximate 1.6-fold higher left ventricle mass indicating that cardiac hypertrophy develops in senescent mice
• hypertrophic phenotype in old mice shows a concentric pattern manifested by reduced left ventricle diameter in systole and diastole
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| hypertrophic cardiomyopathy 10 | DOID:0110316 |
OMIM:608758 |
J:263776 | |
