About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Lsm3em1Caox
endonuclease-mediated mutation 1, Xuetao Cao
MGI:6194617
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Lsm3em1Caox/Lsm3em1Caox involves: C57BL/6J MGI:6194662


Genotype
MGI:6194662
hm1
Allelic
Composition		 Lsm3em1Caox/Lsm3em1Caox
Genetic
Background		 involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lsm3em1Caox mutation (0 available); any Lsm3 mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
decreased susceptibility to Riboviria infection induced morbidity/mortality ( J:262834 )
• following infection of vesicular stomatitis virus with a high dose

immune system
increased circulating interferon-alpha level ( J:262834 )
• following infection of vesicular stomatitis virus with a high dose
increased circulating interferon-beta level ( J:262834 )
• following infection of vesicular stomatitis virus with a high dose
• following infection with influenza virus strain A/Puerto Rico/8/1981
increased circulating interleukin-6 level ( J:262834 )
• following infection with influenza virus strain A/Puerto Rico/8/1981
decreased susceptibility to Riboviria infection ( J:262834 )
• following infection of vesicular stomatitis virus with a moderate dose, mice exhibit increased serum alpha and beta interferon, reduced viral burden, reduced severity of pulmonary inflammation, and decreased mortality compared with wild-type mice
decreased susceptibility to Riboviria infection induced morbidity/mortality ( J:262834 )
• following infection of vesicular stomatitis virus with a high dose
decreased susceptibility to Orthomyxoviridae infection ( J:262834 )
• mice infected with influenza virus strain A/Puerto Rico/8/1981 exhibit higher levels of FBN-beta and IL6 compared with wild-type mice

homeostasis/metabolism
increased circulating interferon-alpha level ( J:262834 )
• following infection of vesicular stomatitis virus with a high dose
increased circulating interferon-beta level ( J:262834 )
• following infection of vesicular stomatitis virus with a high dose
• following infection with influenza virus strain A/Puerto Rico/8/1981
increased circulating interleukin-6 level ( J:262834 )
• following infection with influenza virus strain A/Puerto Rico/8/1981




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory