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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ythdc1tm1.2Jw
targeted mutation 1.2, Jeremy Wang
MGI:6194737
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ythdc1tm1.2Jw/Ythdc1tm1.2Jw involves: 129S4/SvJae * C57BL/6 MGI:6194787
cn2
 		Ythdc1tm1.1Jw/Ythdc1tm1.2Jw
Tg(Ddx4-cre)1Dcas/0 		involves: 129S4/SvJae * C57BL/6 * FVB MGI:6194789
cn3
 		Ythdc1tm1.1Jw/Ythdc1tm1.2Jw
Tg(Zp3-cre)93Knw/0 		involves: 129S4/SvJae * C57BL/6J * FVB MGI:6194788


Genotype
MGI:6194787
hm1
Allelic
Composition		 Ythdc1tm1.2Jw/Ythdc1tm1.2Jw
Genetic
Background		 involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ythdc1tm1.2Jw mutation (0 available); any Ythdc1 mutation (51 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality during organogenesis, complete penetrance ( J:262823 )
• no mice are present at E11.5 with only 1 (out of 9 embryos) present at E8.5




Genotype
MGI:6194789
cn2
Allelic
Composition		 Ythdc1tm1.1Jw/Ythdc1tm1.2Jw
Tg(Ddx4-cre)1Dcas/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Ddx4-cre)1Dcas mutation (2 available)
Ythdc1tm1.1Jw mutation (1 available); any Ythdc1 mutation (51 available)
Ythdc1tm1.2Jw mutation (0 available); any Ythdc1 mutation (51 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal oocyte morphology ( J:262823 )
• oocytes contain cytoplasmic RNA granules unlike in oocytes from control mice
absent oocytes ( J:262823 )
• at 6 months of age and beyond
azoospermia ( J:262823 )
• lack of germ cells at PND25 and in adult male mice
abnormal spermatogonia morphology ( J:262823 )
• fewer spermatogonia in seminiferous tubules at PND8 compared with control mice
absent secondary ovarian follicles ( J:262823 )
• ovaries lack secondary follicles
absent tertiary ovarian follicles ( J:262823 )
• ovaries lack antral follicles
impaired ovarian folliculogenesis ( J:262823 )
• blocked at the primary follicle stage

endocrine/exocrine glands
absent secondary ovarian follicles ( J:262823 )
• ovaries lack secondary follicles
absent tertiary ovarian follicles ( J:262823 )
• ovaries lack antral follicles
impaired ovarian folliculogenesis ( J:262823 )
• blocked at the primary follicle stage

cellular
abnormal oocyte morphology ( J:262823 )
• oocytes contain cytoplasmic RNA granules unlike in oocytes from control mice
absent oocytes ( J:262823 )
• at 6 months of age and beyond
azoospermia ( J:262823 )
• lack of germ cells at PND25 and in adult male mice
abnormal spermatogonia morphology ( J:262823 )
• fewer spermatogonia in seminiferous tubules at PND8 compared with control mice
abnormal DNA-templated transcription ( J:262823 )
• oocytes exhibit widespread m6A-dependent-splicing defects and extensive alternative polyadenylation




Genotype
MGI:6194788
cn3
Allelic
Composition		 Ythdc1tm1.1Jw/Ythdc1tm1.2Jw
Tg(Zp3-cre)93Knw/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6J * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Zp3-cre)93Knw mutation (2 available)
Ythdc1tm1.1Jw mutation (1 available); any Ythdc1 mutation (51 available)
Ythdc1tm1.2Jw mutation (0 available); any Ythdc1 mutation (51 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
impaired ovarian folliculogenesis ( J:262823 )
• blocked at the primary follicle stage

endocrine/exocrine glands
impaired ovarian folliculogenesis ( J:262823 )
• blocked at the primary follicle stage




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory