mortality/aging
• no mice are present at E11.5 with only 1 (out of 9 embryos) present at E8.5
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Allele Symbol Allele Name Allele ID |
Ythdc1tm1.2Jw targeted mutation 1.2, Jeremy Wang MGI:6194737 |
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Summary |
3 genotypes
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• no mice are present at E11.5 with only 1 (out of 9 embryos) present at E8.5
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• oocytes contain cytoplasmic RNA granules unlike in oocytes from control mice
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• at 6 months of age and beyond
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• lack of germ cells at PND25 and in adult male mice
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• fewer spermatogonia in seminiferous tubules at PND8 compared with control mice
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• ovaries lack secondary follicles
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• ovaries lack antral follicles
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• blocked at the primary follicle stage
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• ovaries lack secondary follicles
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• ovaries lack antral follicles
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• blocked at the primary follicle stage
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• oocytes contain cytoplasmic RNA granules unlike in oocytes from control mice
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• at 6 months of age and beyond
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• lack of germ cells at PND25 and in adult male mice
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• fewer spermatogonia in seminiferous tubules at PND8 compared with control mice
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• oocytes exhibit widespread m6A-dependent-splicing defects and extensive alternative polyadenylation
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• blocked at the primary follicle stage
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• blocked at the primary follicle stage
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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