Phenotypes associated with this allele

• Allele Symbol: Lyz2^{em1.1(cre)Elgaz}
• Allele Name: endonuclease-mediated mutation 1.1, Mohamed Elgazzar
• Allele ID: MGI:6195189
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Cebpb^tm1.1Elgaz/Cebpb^tm1.1Elgaz Lyz2^em1.1(cre)Elgaz/Lyz2^+	BALB/cJ-Cebpb^tm1.1Elgaz Lyz2^em1.1Elgaz/Elgaz	MGI:6195657

Genotype
MGI:6195657

cn1

• Allelic Composition: Cebpb^tm1.1Elgaz/Cebpb^tm1.1Elgaz; Lyz2^{em1.1(cre)Elgaz}/Lyz2⁺
• Genetic Background: BALB/cJ-Cebpb^tm1.1Elgaz Lyz2^em1.1Elgaz/Elgaz

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal myeloid cell number ( J:247885 )

• monocytic myeloid-derived suppressor cell and polymorphonuclear myeloid-derived suppressor cell numbers do not increase during CLP-induced sepsis

homeostasis/metabolism

decreased circulating interleukin-10 level ( J:247885 )

• CLP-induced early sepsis results in decreased levels of IL10 and TGFB as compared to control

increased circulating interleukin-6 level ( J:247885 )

• CLP-induced early sepsis results in increased levels of TNFA and IL6 as compared to control

increased circulating tumor necrosis factor level ( J:247885 )

• CLP-induced early sepsis results in increased levels of TNFA and IL6 as compared to control

decreased transforming growth factor beta level ( J:247885 )

• CLP-induced early sepsis results in decreased levels of IL10 and TGFB as compared to control

immune system

decreased circulating interleukin-10 level ( J:247885 )

• CLP-induced early sepsis results in decreased levels of IL10 and TGFB as compared to control

increased circulating interleukin-6 level ( J:247885 )

• CLP-induced early sepsis results in increased levels of TNFA and IL6 as compared to control

increased circulating tumor necrosis factor level ( J:247885 )

• CLP-induced early sepsis results in increased levels of TNFA and IL6 as compared to control

decreased susceptibility to bacterial infection ( J:247885 )

• peritoneal bacteria counts are decreased following induction of peritonitis as compared to wild-type

decreased susceptibility to bacterial infection induced morbidity/mortality ( J:247885 )

• induction of peritonitis by cecal ligation and puncture (CLP), results in 80% increased survival by late sepsis

mortality/aging

decreased susceptibility to bacterial infection induced morbidity/mortality ( J:247885 )

• induction of peritonitis by cecal ligation and puncture (CLP), results in 80% increased survival by late sepsis