Phenotypes associated with this allele

• Allele Symbol: Ifitm5^tm1Pmof
• Allele Name: targeted mutation 1, Pierre Moffatt
• Allele ID: MGI:6195208
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ifitm5^tm1Pmof/Ifitm5^tm1Pmof	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:6195209
ht2	Ifitm5^tm1Pmof/Ifitm5^em1Pmof	involves: 129S1/Sv * 129X1/SvJ * CD-1	MGI:6195296

Genotype
MGI:6195209

hm1

• Allelic Composition: Ifitm5^tm1Pmof/Ifitm5^tm1Pmof
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased body weight ( J:264160 )

♂ • males, but not females, show a transient decrease in body weight only at 3 months of age and not at 6 weeks or 8 months

homeostasis/metabolism

decreased alkaline phosphatase activity ( J:264160 )

• alkaline phosphatase activity is slightly decreased in serum

limbs/digits/tail

short femur ( J:264160 )

♀ • females, but not males, show a transient decrease in femur length at 6 weeks and 3 months of age, but not at 8 months

skeleton

skeleton phenotype ( J:264160 )

N • although mice show minor and transient differences in some bone parameters, these are not seen systematically across all ages and genders, and in general mice are indistinguishable from controls at birth and throughout life, up to more than 8 months of age, with no obvious skeletal abnormalities or spontaneous fractures

N • no alterations in bone material properties, in circulating serum markers of bone turnover, and in bone repair after surgically-induced fracture are seen

short femur ( J:264160 )

♀ • females, but not males, show a transient decrease in femur length at 6 weeks and 3 months of age, but not at 8 months

decreased bone volume ( J:264160 )

♀ • females show a transient 25% decrease in bone volume/tissue volume (BV/TV) only at 6 weeks of age

decreased compact bone area ( J:264160 )

• females exhibit an 11% and 7% decrease in cortical bone area fraction at 6 weeks and 3 months of age, respectively

• males exhibit an approximate 10% decrease in cortical bone areal fraction at 6 weeks but not at 3 months of age

decreased compact bone thickness ( J:264160 )

♀ • females exhibit an 18% and 10% decrease in cortical thickness at 6 weeks and 3 months of age, respectively

abnormal trabecular bone morphology ( J:264160 )

♂ • trabecular bone of 9 week old males shows differences in osteoid volume/bone volume (OV/BV) and osteoblast surface/osteoid surface (Ob.S/OS) parameters, suggesting higher bone rate formation activity

♂ • however, no gross changes in bone morphometry, structure or mineralization are seen

decreased trabecular bone volume ( J:264160 )

♀ • females, but not males, show a transient decrease in trabecular bone volume/tissue volume ratio only at 6 weeks of age and not at 3 of 8 months

decreased bone trabecula number ( J:264160 )

♀ • females exhibit a transient 24% decrease in trabecular number only at 6 weeks of age, but no changes in trabecular thickness

increased bone trabecular spacing ( J:264160 )

♀ • females exhibit a transient 25% increase in trabecular separation only at 6 weeks of age, but no changes in trabecular thickness

increased osteoid volume ( J:264160 )

♂ • trabecular bone of 9 week old males shows differences in osteoid volume/bone volume (OV/BV) ratio

Genotype
MGI:6195296

ht2

• Allelic Composition: Ifitm5^tm1Pmof/Ifitm5^em1Pmof
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

limbs/digits/tail

abnormal limb morphology ( J:255349 )

• forearm is bent at E18.5