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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cebpbtm1.1Elgaz
targeted mutation 1.1, Mohamed Elgazzar
MGI:6195224
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Cebpbtm1.1Elgaz/Cebpbtm1.1Elgaz
Lyz2em1.1(cre)Elgaz/Lyz2+ 		BALB/cJ-Cebpbtm1.1Elgaz Lyz2em1.1Elgaz/Elgaz MGI:6195657


Genotype
MGI:6195657
cn1
Allelic
Composition		 Cebpbtm1.1Elgaz/Cebpbtm1.1Elgaz
Lyz2em1.1(cre)Elgaz/Lyz2+
Genetic
Background		 BALB/cJ-Cebpbtm1.1Elgaz Lyz2em1.1Elgaz/Elgaz
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cebpbtm1.1Elgaz mutation (1 available); any Cebpb mutation (26 available)
Lyz2em1.1(cre)Elgaz mutation (0 available); any Lyz2 mutation (40 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal myeloid cell number ( J:247885 )
• monocytic myeloid-derived suppressor cell and polymorphonuclear myeloid-derived suppressor cell numbers do not increase during CLP-induced sepsis

homeostasis/metabolism
decreased circulating interleukin-10 level ( J:247885 )
• CLP-induced early sepsis results in decreased levels of IL10 and TGFB as compared to control
increased circulating interleukin-6 level ( J:247885 )
• CLP-induced early sepsis results in increased levels of TNFA and IL6 as compared to control
increased circulating tumor necrosis factor level ( J:247885 )
• CLP-induced early sepsis results in increased levels of TNFA and IL6 as compared to control
decreased transforming growth factor beta level ( J:247885 )
• CLP-induced early sepsis results in decreased levels of IL10 and TGFB as compared to control

immune system
decreased circulating interleukin-10 level ( J:247885 )
• CLP-induced early sepsis results in decreased levels of IL10 and TGFB as compared to control
increased circulating interleukin-6 level ( J:247885 )
• CLP-induced early sepsis results in increased levels of TNFA and IL6 as compared to control
increased circulating tumor necrosis factor level ( J:247885 )
• CLP-induced early sepsis results in increased levels of TNFA and IL6 as compared to control
decreased susceptibility to bacterial infection ( J:247885 )
• peritoneal bacteria counts are decreased following induction of peritonitis as compared to wild-type
decreased susceptibility to bacterial infection induced morbidity/mortality ( J:247885 )
• induction of peritonitis by cecal ligation and puncture (CLP), results in 80% increased survival by late sepsis

mortality/aging
decreased susceptibility to bacterial infection induced morbidity/mortality ( J:247885 )
• induction of peritonitis by cecal ligation and puncture (CLP), results in 80% increased survival by late sepsis




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory