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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Srpx2em1Gmsa
endonuclease-mediated mutation 1, Gek-Ming Sia
MGI:6195541
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
ot1
 		Srpx2em1Gmsa/Y C57BL/6J-Srpx2em1Gmsa MGI:6195545


Genotype
MGI:6195545
ot1
Allelic
Composition		 Srpx2em1Gmsa/Y
Genetic
Background		 C57BL/6J-Srpx2em1Gmsa
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Srpx2em1Gmsa mutation (0 available); any Srpx2 mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
abnormal response to social novelty ( J:262853 )
• reduced preference for social novelty in a three-chamber sociability and social novelty task
abnormal vocalization ( J:262853 )
• abnormal ultrasonic vocalization ontogenetic profile with increased vocalizations at P9

nervous system
decreased CNS synapse formation ( J:262853 )
• decreased VGlut2 (Slc17a6) synapse density in layer IV of the somatosensory cortex
• decreased VGlut1 (Slc17a7), VGlut2 (Slc17a6) and VGAT (Slc32a1) synapse densities in the CA2 region of the hippocampus




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory