About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Srpx2em1Gmsa
endonuclease-mediated mutation 1, Gek-Ming Sia
MGI:6195541
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
ot1
 		Srpx2em1Gmsa/Y C57BL/6J-Srpx2em1Gmsa MGI:6195545


Genotype
MGI:6195545
ot1
Allelic
Composition		 Srpx2em1Gmsa/Y
Genetic
Background		 C57BL/6J-Srpx2em1Gmsa
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Srpx2em1Gmsa mutation (0 available); any Srpx2 mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
abnormal response to social novelty ( J:262853 )
• reduced preference for social novelty in a three-chamber sociability and social novelty task
abnormal vocalization ( J:262853 )
• abnormal ultrasonic vocalization ontogenetic profile with increased vocalizations at P9

nervous system
decreased CNS synapse formation ( J:262853 )
• decreased VGlut2 (Slc17a6) synapse density in layer IV of the somatosensory cortex
• decreased VGlut1 (Slc17a7), VGlut2 (Slc17a6) and VGAT (Slc32a1) synapse densities in the CA2 region of the hippocampus




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
10/09/2024
MGI 6.24 		The Jackson Laboratory