mortality/aging
• fewer than expected mice are present at E9.5 and only 1 at E13.5 (no mice are present postnatally)
|
cardiovascular system
• in head and heart vasculature
|
• discontinuous and improperly patterned
|
• abnormal head and heart vasculature at E10.5 that is not as severe as in constitutive knock-outs
|
• discontinuous and improperly patterned
|
• impaired branching in head and heart vasculature
|
• reduced sprouting in head and heart vasculature and of intersomitic vessels
|
• reduced development
|
small heart
(
J:262744
)
• collapsed, small heart chambers
|
embryo
• fetal vessels fail to invade into the developing placenta at E11.5
• however, fetal vessel invasion at E10.5 is normal
|
• reduced thickness at E10.5 and E11.5
|
• reduced branching from major vessels in the yolk sac with vessel fusion and loss of branch hierarchy at E10.5 and E11.5
|
growth/size/body
• at E10.5
|