Phenotypes associated with this allele

• Allele Symbol: Siglece^{tm1.1(SIGLEC16)Avrk}
• Allele Name: targeted mutation 1.1, Ajit Varki
• Allele ID: MGI:6195824
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Siglece^tm1.1(SIGLEC16)Avrk/Siglece^tm1.1(SIGLEC16)Avrk	involves: C57BL/6	MGI:6196015

Genotype
MGI:6196015

hm1

• Allelic Composition: Siglece^{tm1.1(SIGLEC16)Avrk}/Siglece^{tm1.1(SIGLEC16)Avrk}
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal cytokine level ( J:264224 )

• increased levels of IL6, MCP1 and IL12 are observed in serum 1 hour post-bacterial challenge

increased circulating interleukin-12 level ( J:264224 )

• 1 hour post-bacterial challenge

increased circulating interleukin-6 level ( J:264224 )

• 1 hour post-bacterial challenge

decreased susceptibility to bacterial infection ( J:264224 )

• mice infected with E Coli K1 exhibit reduced bacterial counts in blood, spleen and liver as compared to controls

homeostasis/metabolism

abnormal cytokine level ( J:264224 )

• increased levels of IL6, MCP1 and IL12 are observed in serum 1 hour post-bacterial challenge

increased circulating interleukin-12 level ( J:264224 )

• 1 hour post-bacterial challenge

increased circulating interleukin-6 level ( J:264224 )

• 1 hour post-bacterial challenge