Phenotypes associated with this allele

• Allele Symbol: Tg(CAG-Alk*F1174L,-luc)60Jhsc
• Allele Name: transgene insertion 60, Johannes H Schulte
• Allele ID: MGI:6196043
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Tg(CAG-Alk*F1174L,-luc)60Jhsc/0 Tg(Dbh-icre)1Gsc/0 Tg(Th-MYCN)41Waw/0	involves: 129X1/SvJ * BALB/c * C57BL/6 * C57BL/6J * FVB/N	MGI:6196047
cn2	Tg(CAG-Alk*F1174L,-luc)60Jhsc/0 Th^tm1(cre)Te/Th^+	involves: 129X1/SvJ * C57BL/6 * FVB/N	MGI:6196045
cn3	Tg(CAG-Alk*F1174L,-luc)60Jhsc/0 Tg(Dbh-icre)1Gsc/0	involves: C57BL/6 * FVB/N	MGI:6196044

Genotype
MGI:6196047

cn1

• Allelic Composition: Tg(CAG-Alk*F1174L,-luc)60Jhsc/0; Tg(Dbh-icre)1Gsc/0; Tg(Th-MYCN)41Waw/0
• Genetic Background: involves: 129X1/SvJ * BALB/c * C57BL/6 * C57BL/6J * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased neuroblastoma incidence ( J:186696 )

• all mice develop neuroblastomas within 48 days of age

• tumor incidence is higher and time to tumor formation is shorter than in mice expressing only Tg(Th-MYCN)41Waw

• tumors show a reduction in the number of genomic aberrations compared to tumors in mice expressing only Tg(Th-MYCN)41Waw or Tg(CAG-Alk*F1174L,-luc)60Jhsc

• mice bearing tumors treated with TAE-684, an ALK inhibitor, show some regression of tumors

nervous system

increased neuroblastoma incidence ( J:186696 )

• all mice develop neuroblastomas within 48 days of age

• tumor incidence is higher and time to tumor formation is shorter than in mice expressing only Tg(Th-MYCN)41Waw

• tumors show a reduction in the number of genomic aberrations compared to tumors in mice expressing only Tg(Th-MYCN)41Waw or Tg(CAG-Alk*F1174L,-luc)60Jhsc

• mice bearing tumors treated with TAE-684, an ALK inhibitor, show some regression of tumors

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
neuroblastoma		DOID:769		J:186696

Genotype
MGI:6196045

cn2

• Allelic Composition: Tg(CAG-Alk*F1174L,-luc)60Jhsc/0; Th^tm1(cre)Te/Th⁺
• Genetic Background: involves: 129X1/SvJ * C57BL/6 * FVB/N

neoplasm

increased metastatic potential ( J:186696 )

• extensive liver metastases is seen in some mice

increased neuroblastoma incidence ( J:186696 )

• a low number of mice develop palpable neural crest-derived tumors between 130 and 351 days of age resembling neuroblastomas

• tumors form in the neck or abdomen

• the retroperitoneal tumors originate from the adrenal gland

• tumors consist of poorly differentiated cells with large nuclei and sparse neuropil

• neuroblastomas exhibit chromosomal aberrations recapitulating genomic aberrations of human neuroblastomas

endocrine/exocrine glands

adrenal gland hyperplasia ( J:186696 )

• some adrenals appear hypertrophic in mice that do not develop tumors

nervous system

increased neuroblastoma incidence ( J:186696 )

• a low number of mice develop palpable neural crest-derived tumors between 130 and 351 days of age resembling neuroblastomas

• tumors form in the neck or abdomen

• the retroperitoneal tumors originate from the adrenal gland

• tumors consist of poorly differentiated cells with large nuclei and sparse neuropil

• neuroblastomas exhibit chromosomal aberrations recapitulating genomic aberrations of human neuroblastomas

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
neuroblastoma		DOID:769		J:186696

Genotype
MGI:6196044

cn3

• Allelic Composition: Tg(CAG-Alk*F1174L,-luc)60Jhsc/0; Tg(Dbh-icre)1Gsc/0
• Genetic Background: involves: C57BL/6 * FVB/N

neoplasm

increased metastatic potential ( J:186696 )

• extensive liver metastases is seen in some mice

increased neuroblastoma incidence ( J:186696 )

• a low number of mice develop palpable neural crest-derived tumors between 130 and 351 days of age resembling neuroblastomas

• tumors form in the neck or abdomen

• the retroperitoneal tumors originate from the adrenal gland

• tumors consist of poorly differentiated cells with large nuclei and sparse neuropil

• neuroblastomas exhibit chromosomal aberrations recapitulating genomic aberrations of human neuroblastomas

• mice bearing tumors treated with TAE-684, an ALK inhibitor, show tumor regression

endocrine/exocrine glands

adrenal gland hyperplasia ( J:186696 )

• some adrenals appear hypertrophic in mice that do not develop tumors

nervous system

increased neuroblastoma incidence ( J:186696 )

• a low number of mice develop palpable neural crest-derived tumors between 130 and 351 days of age resembling neuroblastomas

• tumors form in the neck or abdomen

• the retroperitoneal tumors originate from the adrenal gland

• tumors consist of poorly differentiated cells with large nuclei and sparse neuropil

• neuroblastomas exhibit chromosomal aberrations recapitulating genomic aberrations of human neuroblastomas

• mice bearing tumors treated with TAE-684, an ALK inhibitor, show tumor regression

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
neuroblastoma		DOID:769		J:186696