Analysis Tools
neoplasm
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• 4 of 16 mice develop abdominal tumors at 36-56 days of age
• tumors originate from the adrenals and/or the ganglion celiacum and some mice have thoracal or superior cervical ganglion tumors
• tumors consist almost entirely of small, round blue cells, similar to human neuroblastomas and express markers of neuroblastoma
• mice treated with JQ1, a compound that downregulates expression of N-myc and suppresses N-myc-driven transcription show increased cell death and reduced proliferation of tumors
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nervous system
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• 4 of 16 mice develop abdominal tumors at 36-56 days of age
• tumors originate from the adrenals and/or the ganglion celiacum and some mice have thoracal or superior cervical ganglion tumors
• tumors consist almost entirely of small, round blue cells, similar to human neuroblastomas and express markers of neuroblastoma
• mice treated with JQ1, a compound that downregulates expression of N-myc and suppresses N-myc-driven transcription show increased cell death and reduced proliferation of tumors
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| neuroblastoma | DOID:769 | J:241988 | ||
