Phenotypes associated with this allele

• Allele Symbol: Klra1^tm1.1Wyok
• Allele Name: targeted mutation 1.1, Wayne M Yokoyama
• Allele ID: MGI:6196148
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Klra1^tm1.1Wyok/Klra1^tm1.1Wyok	involves: BALB/cJ * C57BL/6NTac	MGI:6196214
cx2	H2-D1^b-tm1Bpe/H2-D1^b-tm1Bpe H2-K1^b-tm1Bpe/H2-K1^b-tm1Bpe Klra1^tm1.1Wyok/Klra1^tm1.1Wyok	involves: 129P2/OlaHsd * BALB/cJ * C57BL/6NTac	MGI:6196216
cx3	H2-D1^b-tm1Bpe/H2-D1^b-tm1Bpe H2-K1^b-tm1Bpe/H2-K1^b-tm1Bpe Klra1^tm1.1Wyok/Klra1^tm1.1Wyok Tg(H2-D^d)28Bee/0	involves: 129P2/OlaHsd * BALB/cJ * C57BL/6NTac * DBA/2	MGI:6196218

Genotype
MGI:6196214

hm1

• Allelic Composition: Klra1^tm1.1Wyok/Klra1^tm1.1Wyok
• Genetic Background: involves: BALB/cJ * C57BL/6NTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

hematopoietic system phenotype ( J:252851 )

N • total number of NK cells and number of Ly49A+ NK cells

abnormal natural killer cell mediated cytotoxicity ( J:252851 )

• levels of cytotoxicity of purified Ly49A+ lymphokine-activated killer cells (LAKs) towards normal (H2-B^b haplotype) C1498 target cells at high effector-to-target ratios, using chromium release assays

• increased levels of cytotoxicity of purified Ly49A+ lymphokine-activated killer cells (LAKs) towards Tg(H2-D^d28Bee transgenic C1498 target cells at high effector-to-target ratios, using chromium release assays

immune system

abnormal natural killer cell mediated cytotoxicity ( J:252851 )

• levels of cytotoxicity of purified Ly49A+ lymphokine-activated killer cells (LAKs) towards normal (H2-B^b haplotype) C1498 target cells at high effector-to-target ratios, using chromium release assays

• increased levels of cytotoxicity of purified Ly49A+ lymphokine-activated killer cells (LAKs) towards Tg(H2-D^d28Bee transgenic C1498 target cells at high effector-to-target ratios, using chromium release assays

Genotype
MGI:6196216

cx2

• Allelic Composition: H2-D1^b-tm1Bpe/H2-D1^b-tm1Bpe; H2-K1^b-tm1Bpe/H2-K1^b-tm1Bpe; Klra1^tm1.1Wyok/Klra1^tm1.1Wyok
• Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6NTac

hematopoietic system

hematopoietic system phenotype ( J:252851 )

N • total number of NK cells, number of Ly49A+ NK cells, and their maturation profile as indicated by CD27 and CD11b expression

N • NK cell licensing ratio (% Ifng+ Ly49+ versus Ifng+ Ly49- NK cells) lower than 1 as indicated by Ifng production after stimulation with anti-NK1.1

Genotype
MGI:6196218

cx3

• Allelic Composition: H2-D1^b-tm1Bpe/H2-D1^b-tm1Bpe; H2-K1^b-tm1Bpe/H2-K1^b-tm1Bpe; Klra1^tm1.1Wyok/Klra1^tm1.1Wyok; Tg(H2-D^d)28Bee/0
• Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6NTac * DBA/2

hematopoietic system

hematopoietic system phenotype ( J:252851 )

N • total number of NK cells, number of Ly49A+ NK cells, and their maturation profile as indicated by CD27 and CD11b expression

abnormal NK cell physiology ( J:252851 )

• NK cell licensing ratio (% Ifng+ Ly49+ versus Ifng+ Ly49- NK cells) lower than 1 as indicated by Ifng production after stimulation with anti-NK1.1, compared above 1 in same strain with wild-type Klra1 allele (MGI:6196216)

• substantially increased percentage of Ly49A+ NK cells expressing L49G2, Ly49F and Ly49I, versus reduced percentage in same strain with wild-type Klra1 allele (MGI:6196216)

immune system

abnormal NK cell physiology ( J:252851 )

• NK cell licensing ratio (% Ifng+ Ly49+ versus Ifng+ Ly49- NK cells) lower than 1 as indicated by Ifng production after stimulation with anti-NK1.1, compared above 1 in same strain with wild-type Klra1 allele (MGI:6196216)

• substantially increased percentage of Ly49A+ NK cells expressing L49G2, Ly49F and Ly49I, versus reduced percentage in same strain with wild-type Klra1 allele (MGI:6196216)