Analysis Tools
behavior/neurological
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• hindlimb clasping is observed in 18 month old mice
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• less time spent on rotating rods as compared to controls at 12 months of age
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• reduced rearing is observed by 18 months of age
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cellular
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• increased cell death in neurons after treatment with 10um glutamate
• increase in total and cell surface levels of glutamate receptors
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• increase in autophagosome/lysosome proteins in spinal motor neuron axons of 9 month old mice
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hematopoietic system
microgliosis
(
J:264431
)
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• increased astrogliosis and microgliosis is observed in the spinal cord of 18 month old mice
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homeostasis/metabolism
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• increased cell death in neurons after treatment with 10um glutamate
• increase in total and cell surface levels of glutamate receptors
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immune system
microgliosis
(
J:264431
)
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• increased astrogliosis and microgliosis is observed in the spinal cord of 18 month old mice
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muscle
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• decrease in gastrocnemius muscle weight in 24 month old males
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• myofiber de/regeneration, decrease in size of muscle fiber, and inflammatory cell infiltration of gastrocnemius muscle in 24 month old males
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nervous system
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• increased cell death in neurons after treatment with 10um glutamate
• increase in total and cell surface levels of glutamate receptors
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microgliosis
(
J:264431
)
|
• increased astrogliosis and microgliosis is observed in the spinal cord of 18 month old mice
|
astrocytosis
(
J:264431
)
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• increased astrogliosis and microgliosis is observed in the spinal cord of 18 month old mice
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• accumulation of acetylated alpha-tubulin in spinal motor neuron axons of 9 month old mice
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• decrease in numbers of spinal motor neurons in lumbar spinal cord in 18 month, but not 9 month old mice
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• neuromuscular junctions (NMJ) in 18 month old mice are partially or fully fragmented
• severe denervation in NMJ of 18 month old mice
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limbs/digits/tail
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• decrease in gastrocnemius muscle weight in 24 month old males
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